Detail of EN10753092


Summary

    Name:LSTP_STASI
    FullName:Lysostaphin,lysostaphin
    Producer Organism:Staphylococcus simulans
    Sequence Length:493
    Mass:53091
    Calculated Isoelectric Point:5.27
    Target:S. aureus,CNS
    Link:P10547
    Function:Lyses staphylococcal cells by hydrolyzing the polyglycine interpeptide bridges of the peptidoglycan.

Domains

IPR003646:278-367
IPR003646:411-481
InterPro

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493

  1  [239-382]:IPR011055,Duplicated hybrid motif?
  2  [411-481]:IPR003646,SH3-like domain, bacterial-type
  3  [278-367]:IPR003646,Peptidase M23?

GO term prediction

    No GO term prediction

Structures

    No structs found on enzybiotics database

Sequence

MKKTKNNYYTRPLAIGLSTFALASIVYGGIQNETHASEKSNMDVSKKVAEVETSKAPVEN
TAEVETSKAPVENTAEVETSKAPVENTAEVETSKAPVENTAEVETSKAPVENTAEVETSK
APVENTAEVETSKAPVENTAEVETSKAPVENTAEVETSKAPVENTAEVETSKAPVENTAE
VETSKAPVENTAEVETSKAPVENTAEVETSKAPVENTAEVETSKAPVENTAEVETSKALV
QNRTALRAATHEHSAQWLNNYKKGYGYGPYPLGINGGMHYGVDFFMNIGTPVKAISSGKI
VEAGWSNYGGGNQIGLIENDGVHRQWYMHLSKYNVKVGDYVKAGQIIGWSGSTGYSTAPH
LHFQRMVNSFSNSTAQDPMPFLKSAGYGKAGGTVTPTPNTGWKTNKYGTLYKSESASFTP
NTDIITRTTGPFRSMPQSGVLKAGQTIHYDEVMKQDGHVWVGYTGNSGQRIYLPVRTWNK
STNTLGVLWGTIK
  BlastP to EnzyBase2

Activity

  •   Antibacterial Activities
  •   1  Flora:S. aureus  MIC:2.5ug/ml  Method:agar-dilu  [Pubmed:181936]
  •   2  Flora:S. capitis  MIC:60ug/ml  Method:agar-dilu  [Pubmed:181936]
  •   3  Flora:S. cohnii  MIC:8ug/ml  Method:agar-dilu  [Pubmed:181936]
  •   4  Flora:S. epidermidis  MIC:16ug/ml  Method:agar-dilu  [Pubmed:181936]
  •   5  Flora:S. haemolyticus  MIC:50ug/ml  Method:agar-dilu  [Pubmed:181936]
  •   6  Flora:S. hominis  MIC:60ug/ml  Method:agar-dilu  [Pubmed:181936]
  •   7  Flora:S. saprophyticus  MIC:16ug/ml  Method:agar-dilu  [Pubmed:181936]
  •   8  Flora:S. simulans  MIC:4ug/ml  Method:agar-dilu  [Pubmed:181936]
  •   9  Flora:S. warneri  MIC:40ug/ml  Method:agar-dilu  [Pubmed:181936]
  •   10  Flora:S. xylosus  MIC:14ug/ml  Method:agar-dilu  [Pubmed:181936]

References

  [1]  Goetz F.,Thumm G.,  Studies on prolysostaphin processing and characterization of the lysostaphin immunity factor (Lif) of Staphylococcus simulans biovar staphylolyticus.  Mol. Microbiol.,1997,(23):1251-1265  [MEDLINE:97260121]
  [2]  Novick R.P.,Gruss A.D.,Recsei P.A.,  Cloning, sequence, and expression of the lysostaphin gene from Staphylococcus simulans.  Proc. Natl. Acad. Sci. U.S.A.,1987,(84):1127-1131  [MEDLINE:87147226]