Detail of EN1412232


Summary

    Name:SLE1_STAAU
    FullName:N-acetylmuramoyl-L-alanine amidase sle1,Sle1
    Producer Organism:Staphylococcus aureus
    Sequence Length:334
    Mass:35836
    Calculated Isoelectric Point:9.99
    Target:S. aureus
    Link:P0C1U7
    Function:Peptidoglycan hydrolase involved in the splitting of the septum during cell division. Binds to both alpha and beta-chains of human fibrinogen as well as fibronectin, which suggests a role in the colonization of host factor-coated material or host tissue. Also exhibits lytic activity against S.carnosus and S.aureus cells but not against M.luteus cells.

Domains

InterPro

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334

  1  []:IPR007921,CHAP
  2  []:IPR018392,Peptidoglycan-bd_lysin
  3  []:IPR002482,Peptidoglycan-bd_Lysin_subgr

GO term prediction

    No GO term prediction

Structures

    No structs found on enzybiotics database

Sequence

MQKKVIAAIIGTSAISAVAATQANAATTHTVKPGESVWAISNKYGISIAKLKSLNNLTSN
LIFPNQVLKVSGSSNSTSNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQNIMRLNG
LNNFFIYPGQKLKVSGTASSSNAASNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQ
KIMSLNGLNNFFIYPGQKLKVTGNASTNSGSATTTNRGYNTPVFSHQNLYTWGQCTYHVF
NRRAEIGKGISTYWWNANNWDNAAAADGYTIDNRPTVGSIAQTDVGYYGHVMFVERVNND
GSILVSEMNYSAAPGILTYRTVPAYQVNNYRYIH
  BlastP to EnzyBase2

Activity

    No MICs found on enzybiotics database

References

  [1]  Peters G.,Hussain M.S.,Hartleib J.,Heilmann C.,  The multifunctional Staphylococcus aureus autolysin aaa mediates adherence to immobilized fibrinogen and fibronectin.  Infect. Immun.,2005,(73):4793-4802  [PubMed:16040992]