Detail of EN18723640

Summary

    Name:LYSC_PHACO
    FullName:Lysozyme C
    Producer Organism:Phasianus colchicus colchicus
    Sequence Length:147
    Mass:16166
    Calculated Isoelectric Point:9.21
    Target:Gram-positive bacteria
    Link:P00702
    Function:Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Domains

InterPro

100

147

  1  []:IPR001916,Glyco_hydro_22
  2  []:IPR019799,Glyco_hydro_22_CS
  3  []:IPR000974,Glyco_hydro_22_lys
  4  []:IPR023346,Lysozyme-like_dom

GO term prediction

1 GO:0003796, the lysozyme activity
2 GO:0016998, the cell wall macromolecule catabolic process

Structures

1
1GHLMethod:X-ray
Chains:A/B=18-147
2
1JHLMethod:X-ray
Chains:A=19-147

Sequence

MRSLLILVLCFLPLAAPGKVYGRCELAAAMKRMGLDNYRGYSLGNWVCAAKFESNFNTGA
TNRNTDGSTDYGILQINSRWWCNDGRTPGSKNLCHIPCSALLSSDITASVNCAKKIVSDG
NGMNAWVAWRKHCKGTDVNVWIRGCRL

BlastP to EnzyBase2

Activity

No MICs found on enzybiotics database

References

  [1]  Alzari P.M.,Souchon H.,Lescar J.,  Crystal structures of pheasant and guinea fowl egg-white lysozymes.  Protein Sci.,1994,(3):788-798  [MEDLINE:94339839]
  [2]  Eisele J.L.,Bhat T.N.,Bentley G.A.,Alzari P.M.,Chitarra V.,  Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex.  Proc. Natl. Acad. Sci. U.S.A.,1993,(90):7711-7715  [MEDLINE:93361517]
  [3]  Wilson A.C.,Krummel B.M.,Weisman L.S.,  Evolutionary shift in the site of cleavage of prelysozyme.  J. Biol. Chem.,1986,(261):2309-2313  [MEDLINE:86111933]
  [4]  Jolles P.,Schoentgen F.,Prager E.M.,Ibrahimi I.M.,Jolles J.,  Amino acid sequence of pheasant lysozyme. Evolutionary change affecting processing of prelysozyme.  Biochemistry,1979,(18):2744-2752  [MEDLINE:80000413]