Detail of EN36484538

Summary

    Name:ENVC_ECOLI
    FullName:Murein hydrolase activator EnvC,YibP,EnvC
    Producer Organism:Escherichia coli (strain K12)
    Sequence Length:419
    Mass:46595
    Calculated Isoelectric Point:10.49
    Target:E. coli
    Link:P37690
    Function:Activator of the cell wall hydrolases AmiA and AmiB. Required for septal murein cleavage and daughter cell separation during cell division. In vitro, exhibits weak endoproteolytic activity on beta-casein.

Domains

InterPro

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419

1 []:IPR011055,Dup_hybrid_motif
2 []:IPR016047,Peptidase_M23

GO term prediction

No GO term prediction

Structures

No structs found on enzybiotics database

Sequence

MTRAVKPRRFAIRPIIYASVLSAGVLLCAFSAHADERDQLKSIQADIAAKERAVRQKQQQ
RASLLAQLKKQEEAISEATRKLRETQNTLNQLNKQIDEMNASIAKLEQQKAAQERSLAAQ
LDAAFRQGEHTGIQLILSGEESQRGQRLQAYFGYLNQARQETIAQLKQTREEVAMQRAEL
EEKQSEQQTLLYEQRAQQAKLTQALNERKKTLAGLESSIQQGQQQLSELRANESRLRNSI
ARAEAAAKARAEREAREAQAVRDRQKEATRKGTTYKPTESEKSLMSRTGGLGAPRGQAFW
PVRGPTLHRYGEQLQGELRWKGMVIGASEGTEVKAIADGRVILADWLQGYGLVVVVEHGK
GDMSLYGYNQSALVSVGSQVRAGQPIALVGSSGGQGRPSLYFEIRRQGQAVNPQPWLGR

BlastP to EnzyBase2

Activity

No MICs found on enzybiotics database

References

  [1]  Bernhardt T.G.,Dinh T.,Parzych K.R.,Uehara T.,  Daughter cell separation is controlled by cytokinetic ring-activated cell wall hydrolysis.  EMBO J.,2010,(29):1412-1422  [PubMed:20300061]
  [2]  Bernhardt T.G.,Dinh T.,Uehara T.,  LytM-domain factors are required for daughter cell separation and rapid ampicillin-induced lysis in Escherichia coli.  J. Bacteriol.,2009,(191):5094-5107  [PubMed:19525345]
  [3]  Isono K.,Fujita K.,Yamamoto Y.,Morooka N.,Hayashi K.,  Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.  Mol. Syst. Biol.,2006,(2):0-0  [PubMed:16738553]
  [4]  de Boer P.A.,Bernhardt T.G.,  Screening for synthetic lethal mutants in Escherichia coli and identification of EnvC (YibP) as a periplasmic septal ring factor with murein hydrolase activity.  Mol. Microbiol.,2004,(52):1255-1269  [PubMed:15165230]
  [5]  Yamamoto Y.,Park J.T.,Karibian D.,Narita S.,Hara H.,  Identification and characterization of the Escherichia coli envC gene encoding a periplasmic coiled-coil protein with putative peptidase activity.  FEMS Microbiol. Lett.,2002,(212):229-236  [PubMed:12113939]
  [6]  Hiraga S.,Wada C.,Maeda M.,Yamazoe M.,Ichimura T.,  Proteolytic activity of YibP protein in Escherichia coli.  J. Bacteriol.,2002,(184):2595-2602  [PubMed:11976287]
  [7]  Burland V.,Perna N.T.,Bloch C.A.,Plunkett G. III,Blattner F.R.,  The complete genome sequence of Escherichia coli K-12.  Science,1997,(277):1453-1474  [MEDLINE:97426617]
  [8]  Blattner F.R.,Plunkett G. III,Daniels D.L.,Burland V.,Sofia H.J.,  Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.  Nucleic Acids Res.,1994,(22):2576-2586  [MEDLINE:94316500]