Detail of EN4499312

Summary

    Name:LYZ1_MOUSE
    FullName:Lysozyme C-1
    Producer Organism:Mus musculus
    Sequence Length:148
    Mass:16794
    Calculated Isoelectric Point:9.7
    Target:Gram-positive bacteria
    Link:P17897
    Function:Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz1 is active against a range of Gram-postive and Gram-negative bacteria. Less effective than Lyz2 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria.

Domains

InterPro

100

148

  1  []:IPR001916,Glyco_hydro_22
  2  []:IPR019799,Glyco_hydro_22_CS
  3  []:IPR000974,Glyco_hydro_22_lys
  4  []:IPR023346,Lysozyme-like_dom

GO term prediction

1 GO:0003796, the lysozyme activity
2 GO:0016998, the cell wall macromolecule catabolic process

Structures

No structs found on enzybiotics database

Sequence

MKALLTLGLLLLSVTAQAKVYNRCELARILKRNGMDGYRGVKLADWVCLAQHESNYNTRA
TNYNRGDRSTDYGIFQINSRYWCNDGKTPRSKNACGINCSALLQDDITAAIQCAKRVVRD
PQGIRAWVAWRTQCQNRDLSQYIRNCGV

BlastP to EnzyBase2

Activity

No MICs found on enzybiotics database

References

  [1]    The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).  Genome Res.,2004,(14):2121-2127  [PubMed:15489334]
  [2]  Weaver T.E.,Na C.-L.,Graf T.,Faust N.,Markart P.,  Comparison of the microbicidal and muramidase activities of mouse lysozyme M and P.  Biochem. J.,2004,(380):385-392  [PubMed:14977423]
  [3]  Wilson A.C.,Cortopassi G.A.,  Recent origin of the P lysozyme gene in mice.  Nucleic Acids Res.,1990,(18):1911-1911  [MEDLINE:90245605]
  [4]  Renkawitz R.,Cross M.,  Repetitive sequence involvement in the duplication and divergence of mouse lysozyme genes.  EMBO J.,1990,(9):1283-1288  [MEDLINE:90214640]