Detail of EN50664856

Summary

    Name:LYZ2_MOUSE
    FullName:Lysozyme C-2
    Producer Organism:Mus musculus
    Sequence Length:148
    Mass:16689
    Calculated Isoelectric Point:8.91
    Target:Gram-positive bacteria
    Link:P08905
    Function:Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz2 is active against a range of Gram-positive and Gram-negative bacteria. More effective than Lyz1 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria.

Domains

InterPro

100

148

  1  []:IPR001916,Glyco_hydro_22
  2  []:IPR019799,Glyco_hydro_22_CS
  3  []:IPR000974,Glyco_hydro_22_lys
  4  []:IPR023346,Lysozyme-like_dom

GO term prediction

1 GO:0003796, the lysozyme activity
2 GO:0016998, the cell wall macromolecule catabolic process

Structures

1
1IVMMethod:NMR
Chains:A=19-148

Sequence

MKTLLTLGLLLLSVTAQAKVYERCEFARTLKRNGMAGYYGVSLADWVCLAQHESNYNTRA
TNYNRGDQSTDYGIFQINSRYWCNDGKTPRAVNACGINCSALLQDDITAAIQCAKRVVRD
PQGIRAWVAWRAHCQNRDLSQYIRNCGV

BlastP to EnzyBase2

Activity

No MICs found on enzybiotics database

References

  [1]  Frith M.C.,Gough J.,Katayama S.,Kasukawa T.,Carninci P.,  The transcriptional landscape of the mammalian genome.  Science,2005,(309):1559-1563  [PubMed:16141072]
  [2]  Liu L.,Liao H.-I.,Gabayan V.,Thapa D.R.,Cole A.M.,  Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M.  J. Leukoc. Biol.,2005,(78):1081-1085  [PubMed:16204648]
  [3]    The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).  Genome Res.,2004,(14):2121-2127  [PubMed:15489334]
  [4]  Akinbi H.T.,Weaver T.E.,Korfhagen T.R.,Markart P.,  Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infection.  Am. J. Respir. Crit. Care Med.,2004,(169):454-458  [PubMed:14617511]
  [5]  Weaver T.E.,Na C.-L.,Graf T.,Faust N.,Markart P.,  Comparison of the microbicidal and muramidase activities of mouse lysozyme M and P.  Biochem. J.,2004,(380):385-392  [PubMed:14977423]
  [6]  Pederson B.,Clausen B.E.,Kim H.R.,Chi H.H.,Sinha P.,  Mouse lysozyme-M knockout mice reveal how the self-determinant hierarchy shapes the T cell repertoire against this circulating self antigen in wild-type mice.  J. Immunol.,2004,(173):1763-1771  [PubMed:15265906]
  [7]  Oren A.,Liu L.,Liao H.-I.,Gabayan V.,Ganz T.,  Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycan.  Blood,2003,(101):2388-2392  [PubMed:12411294]
  [8]  Imoto T.,Ueda T.,Obita T.,  Solution structure and activity of mouse lysozyme M.  Cell. Mol. Life Sci.,2003,(60):176-184  [PubMed:12613666]
  [9]  Renkawitz R.,Wedel A.,Mangelsdorf I.,Cross M.,  Mouse lysozyme M gene: isolation, characterization, and expression studies.  Proc. Natl. Acad. Sci. U.S.A.,1988,(85):6232-6236  [MEDLINE:88320416]