Detail of EN59495702


Summary

    Name:ALE1_STACP
    FullName:Glycyl-glycine endopeptidase ALE-1,ALE-1
    Producer Organism:Staphylococcus capitis
    Sequence Length:362
    Mass:39350
    Calculated Isoelectric Point:9.57
    Target:S. aureus
    Link:O05156
    Function:Lyses staphylococcal cells by hydrolyzing the polyglycine interpeptide bridges of the peptidoglycan.

Domains

InterPro

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362

  1  []:IPR011055,Dup_hybrid_motif
  2  []:IPR016047,Peptidase_M23
  3  []:IPR003646,SH3-like_bac
  4  []:IPR013667,SH3_5_bac

GO term prediction

    No GO term prediction

Structures

  •   1
    1R77    Method:X-ray
    Chains:A/B=271-362

Sequence

MDTNRKFTLVKSLSIGLGTFLVGSVFLTVNDEASASTKVDAPKVEQEAPAKADAPKVEQE
APAKADAPKVEQEAPAKVDAPKVEQEAPAKVDAPKVEQEAPAKADAPKVEQKRTFVREAA
QSNHSASWLNNYKKGYGYGPYPLGINGGNHYGVDFFMNVGTPVRAISDGKIVEAGWTNYG
GGNEIGLVENDGVHRQWYMHLSKFNVKVGDRVKAGQIIGWSGSTGYSTAPHLHFQRMTNS
FSNNTAQDPMPFLKSAGYGSNSTSSSNNNGYKTNKYGTLYKSESASFTANTDIITRLTGP
FRSMPQSGVLRKGLTIKYDEVMKQDGHVWVGYNTNSGKRVYLPVRTWNESTGELGPLWGT
IK
  BlastP to EnzyBase2

Activity

    No MICs found on enzybiotics database

References

  [1]  Ohara M.,Nishida T.,Komatsuzawa H.,Aoki S.,Fujiwara T.,  Mutation analysis of the histidine residues in the glycylglycine endopeptidase ALE-1.  J. Bacteriol.,2005,(187):480-487  [PubMed:15629919]
  [2]  Komatsuzawa H.,Ohara M.,Akiyama T.,Fujiwara T.,Sugai M.,  Purification and molecular characterization of glycylglycine endopeptidase produced by Staphylococcus capitis EPK1.  J. Bacteriol.,1997,(179):1193-1202  [MEDLINE:97175547]