Detail of EN61355328


Summary

    Name:LYSC_HUMAN
    FullName:Lysozyme C,human lysozyme
    Producer Organism:Homo sapiens
    Sequence Length:148
    Mass:16537
    Calculated Isoelectric Point:9.35
    Target:Gram-positive bacteria
    Link:P61626
    Function:Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Domains

IPR023346:19-147
InterPro

50
100
148

  1  [19-147]:IPR023346,Lysozyme-like domain

GO term prediction

    No GO term prediction

Structures

  •   1
    133L    Method:X-ray
    Chains:A=19-148
  •   2
    134L    Method:X-ray
    Chains:A=19-148
  •   3
    1B5U    Method:X-ray
    Chains:A=19-148
  •   4
    1B5V    Method:X-ray
    Chains:A=19-148
  •   5
    1B5W    Method:X-ray
    Chains:A=19-148
  •   6
    1B5X    Method:X-ray
    Chains:A=19-148
  •   7
    1B5Y    Method:X-ray
    Chains:A=19-148
  •   8
    1B5Z    Method:X-ray
    Chains:A/B=19-148
  •   9
    1B7L    Method:X-ray
    Chains:A=19-148
  •   10
    1B7M    Method:X-ray
    Chains:A=19-148
  •   11
    1B7N    Method:X-ray
    Chains:A=19-148
  •   12
    1B7O    Method:X-ray
    Chains:A=19-148
  •   13
    1B7P    Method:X-ray
    Chains:A=19-148
  •   14
    1B7Q    Method:X-ray
    Chains:A=19-148
  •   15
    1B7R    Method:X-ray
    Chains:A=19-148
  •   16
    1B7S    Method:X-ray
    Chains:A=19-148
  •   17
    1BB3    Method:X-ray
    Chains:A/B=19-148
  •   18
    1BB4    Method:X-ray
    Chains:A/B=19-148
  •   19
    1BB5    Method:X-ray
    Chains:A/B=19-148
  •   20
    1C43    Method:X-ray
    Chains:A=20-148
  •   21
    1C45    Method:X-ray
    Chains:A=20-148
  •   22
    1C46    Method:X-ray
    Chains:A=18-148
  •   23
    1C7P    Method:X-ray
    Chains:A=19-148
  •   24
    1CJ6    Method:X-ray
    Chains:A=19-148
  •   25
    1CJ7    Method:X-ray
    Chains:A=19-148
  •   26
    1CJ8    Method:X-ray
    Chains:A=19-148
  •   27
    1CJ9    Method:X-ray
    Chains:A=19-148
  •   28
    1CKC    Method:X-ray
    Chains:A=19-148
  •   29
    1CKD    Method:X-ray
    Chains:A=19-148
  •   30
    1CKF    Method:X-ray
    Chains:A=19-148
  •   31
    1CKG    Method:X-ray
    Chains:A/B=19-148
  •   32
    1CKH    Method:X-ray
    Chains:A=19-148
  •   33
    1D6P    Method:X-ray
    Chains:A=19-148
  •   34
    1D6Q    Method:X-ray
    Chains:A=19-148
  •   35
    1DI3    Method:X-ray
    Chains:A=19-148
  •   36
    1DI4    Method:X-ray
    Chains:A=19-148
  •   37
    1DI5    Method:X-ray
    Chains:A=19-148
  •   38
    1EQ4    Method:X-ray
    Chains:A=19-148
  •   39
    1EQ5    Method:X-ray
    Chains:A=19-148
  •   40
    1EQE    Method:X-ray
    Chains:A=19-148
  •   41
    1GAY    Method:X-ray
    Chains:A=21-148
  •   42
    1GAZ    Method:X-ray
    Chains:A=21-148
  •   43
    1GB0    Method:X-ray
    Chains:A=21-148
  •   44
    1GB2    Method:X-ray
    Chains:A=21-148
  •   45
    1GB3    Method:X-ray
    Chains:A=21-148
  •   46
    1GB5    Method:X-ray
    Chains:A=19-148
  •   47
    1GB6    Method:X-ray
    Chains:A=19-148
  •   48
    1GB7    Method:X-ray
    Chains:A=19-148
  •   49
    1GB8    Method:X-ray
    Chains:A=19-148
  •   50
    1GB9    Method:X-ray
    Chains:A=19-148
  •   51
    1GBO    Method:X-ray
    Chains:A=19-148
  •   52
    1GBW    Method:X-ray
    Chains:A=19-148
  •   53
    1GBX    Method:X-ray
    Chains:A=19-148
  •   54
    1GBY    Method:X-ray
    Chains:A=19-148
  •   55
    1GBZ    Method:X-ray
    Chains:A=19-148
  •   56
    1GDW    Method:X-ray
    Chains:A=19-148
  •   57
    1GDX    Method:X-ray
    Chains:A=19-148
  •   58
    1GE0    Method:X-ray
    Chains:A=19-148
  •   59
    1GE1    Method:X-ray
    Chains:A=19-148
  •   60
    1GE2    Method:X-ray
    Chains:A=19-148
  •   61
    1GE3    Method:X-ray
    Chains:A=19-148
  •   62
    1GE4    Method:X-ray
    Chains:A=19-148
  •   63
    1GEV    Method:X-ray
    Chains:A=19-148
  •   64
    1GEZ    Method:X-ray
    Chains:A=19-148
  •   65
    1GF0    Method:X-ray
    Chains:A=19-148
  •   66
    1GF3    Method:X-ray
    Chains:A=19-148
  •   67
    1GF4    Method:X-ray
    Chains:A=19-148
  •   68
    1GF5    Method:X-ray
    Chains:A=19-148
  •   69
    1GF6    Method:X-ray
    Chains:A=19-148
  •   70
    1GF7    Method:X-ray
    Chains:A=19-148
  •   71
    1GF8    Method:X-ray
    Chains:A=21-148
  •   72
    1GF9    Method:X-ray
    Chains:A=21-148
  •   73
    1GFA    Method:X-ray
    Chains:A=21-148
  •   74
    1GFE    Method:X-ray
    Chains:A=21-148
  •   75
    1GFG    Method:X-ray
    Chains:A=21-148
  •   76
    1GFH    Method:X-ray
    Chains:A=19-148
  •   77
    1GFJ    Method:X-ray
    Chains:A=19-148
  •   78
    1GFK    Method:X-ray
    Chains:A=19-148
  •   79
    1GFR    Method:X-ray
    Chains:A=19-148
  •   80
    1GFT    Method:X-ray
    Chains:A=19-148
  •   81
    1GFU    Method:X-ray
    Chains:A=19-148
  •   82
    1GFV    Method:X-ray
    Chains:A=19-148
  •   83
    1HNL    Method:X-ray
    Chains:A=19-148
  •   84
    1I1Z    Method:X-ray
    Chains:A=19-148
  •   85
    1I20    Method:X-ray
    Chains:A=19-148
  •   86
    1I22    Method:X-ray
    Chains:A/B/C/D=19-148
  •   87
    1INU    Method:X-ray
    Chains:A=19-148
  •   88
    1IOC    Method:X-ray
    Chains:A=19-148
  •   89
    1IP1    Method:X-ray
    Chains:A=19-148
  •   90
    1IP2    Method:X-ray
    Chains:A=19-148
  •   91
    1IP3    Method:X-ray
    Chains:A/B=19-148
  •   92
    1IP4    Method:X-ray
    Chains:A=19-148
  •   93
    1IP5    Method:X-ray
    Chains:A=19-148
  •   94
    1IP6    Method:X-ray
    Chains:A=19-148
  •   95
    1IP7    Method:X-ray
    Chains:A/B=19-146
  •   96
    1IWT    Method:X-ray
    Chains:A=19-148
  •   97
    1IWU    Method:X-ray
    Chains:A=19-148
  •   98
    1IWV    Method:X-ray
    Chains:A=19-148
  •   99
    1IWW    Method:X-ray
    Chains:A=19-148
  •   100
    1IWX    Method:X-ray
    Chains:A=19-148
  •   101
    1IWY    Method:X-ray
    Chains:A=19-148
  •   102
    1IWZ    Method:X-ray
    Chains:A=19-148
  •   103
    1IX0    Method:X-ray
    Chains:A=19-148
  •   104
    1IY3    Method:NMR
    Chains:A=19-148
  •   105
    1IY4    Method:NMR
    Chains:A=19-148
  •   106
    1JKA    Method:X-ray
    Chains:A=19-148
  •   107
    1JKB    Method:X-ray
    Chains:A=19-148
  •   108
    1JKC    Method:X-ray
    Chains:A=19-148
  •   109
    1JKD    Method:X-ray
    Chains:A=19-148
  •   110
    1JSF    Method:X-ray
    Chains:A=19-148
  •   111
    1JWR    Method:X-ray
    Chains:A=19-148
  •   112
    1LAA    Method:X-ray
    Chains:A=19-148
  •   113
    1LHH    Method:X-ray
    Chains:A=19-148
  •   114
    1LHI    Method:X-ray
    Chains:A=19-148
  •   115
    1LHJ    Method:X-ray
    Chains:A=19-148
  •   116
    1LHK    Method:X-ray
    Chains:A=19-148
  •   117
    1LHL    Method:X-ray
    Chains:A=19-148
  •   118
    1LHM    Method:X-ray
    Chains:A=19-148
  •   119
    1LMT    Method:X-ray
    Chains:A=19-148
  •   120
    1LOZ    Method:X-ray
    Chains:A=19-148
  •   121
    1LYY    Method:X-ray
    Chains:A=19-148
  •   122
    1LZ1    Method:X-ray
    Chains:A=19-148
  •   123
    1LZ4    Method:X-ray
    Chains:A=19-148
  •   124
    1LZ5    Method:X-ray
    Chains:A=19-144
  •   125
    1LZ6    Method:X-ray
    Chains:A=19-148
  •   126
    1LZR    Method:X-ray
    Chains:A=19-148
  •   127
    1LZS    Method:X-ray
    Chains:A/B=19-148
  •   128
    1OP9    Method:X-ray
    Chains:B=19-148
  •   129
    1OUA    Method:X-ray
    Chains:A=19-148
  •   130
    1OUB    Method:X-ray
    Chains:A=19-148
  •   131
    1OUC    Method:X-ray
    Chains:A=19-148
  •   132
    1OUD    Method:X-ray
    Chains:A=19-148
  •   133
    1OUE    Method:X-ray
    Chains:A=19-148
  •   134
    1OUF    Method:X-ray
    Chains:A=19-147
  •   135
    1OUG    Method:X-ray
    Chains:A=21-148
  •   136
    1OUH    Method:X-ray
    Chains:A=19-148
  •   137
    1OUI    Method:X-ray
    Chains:A=19-148
  •   138
    1OUJ    Method:X-ray
    Chains:A=19-148
  •   139
    1QSW    Method:X-ray
    Chains:A/B/C/D=19-148
  •   140
    1RE2    Method:X-ray
    Chains:A=19-148
  •   141
    1REM    Method:X-ray
    Chains:A=19-148
  •   142
    1REX    Method:X-ray
    Chains:A=19-148
  •   143
    1REY    Method:X-ray
    Chains:A=19-148
  •   144
    1REZ    Method:X-ray
    Chains:A=19-148
  •   145
    1TAY    Method:X-ray
    Chains:A=19-148
  •   146
    1TBY    Method:X-ray
    Chains:A=19-148
  •   147
    1TCY    Method:X-ray
    Chains:A=19-148
  •   148
    1TDY    Method:X-ray
    Chains:A=19-148
  •   149
    1UBZ    Method:X-ray
    Chains:A=19-148
  •   150
    1W08    Method:X-ray
    Chains:A=19-148
  •   151
    1WQM    Method:X-ray
    Chains:A=19-148
  •   152
    1WQN    Method:X-ray
    Chains:A=19-148
  •   153
    1WQO    Method:X-ray
    Chains:A=19-148
  •   154
    1WQP    Method:X-ray
    Chains:A=19-148
  •   155
    1WQQ    Method:X-ray
    Chains:A=19-148
  •   156
    1WQR    Method:X-ray
    Chains:A=19-148
  •   157
    1YAM    Method:X-ray
    Chains:A=19-148
  •   158
    1YAN    Method:X-ray
    Chains:A=19-148
  •   159
    1YAO    Method:X-ray
    Chains:A=19-148
  •   160
    1YAP    Method:X-ray
    Chains:A=19-148
  •   161
    1YAQ    Method:X-ray
    Chains:A=19-148
  •   162
    207L    Method:X-ray
    Chains:A=19-148
  •   163
    208L    Method:X-ray
    Chains:A=19-148
  •   164
    2BQA    Method:X-ray
    Chains:A=19-148
  •   165
    2BQB    Method:X-ray
    Chains:A=19-148
  •   166
    2BQC    Method:X-ray
    Chains:A=19-148
  •   167
    2BQD    Method:X-ray
    Chains:A=19-148
  •   168
    2BQE    Method:X-ray
    Chains:A=19-148
  •   169
    2BQF    Method:X-ray
    Chains:A=19-148
  •   170
    2BQG    Method:X-ray
    Chains:A=19-148
  •   171
    2BQH    Method:X-ray
    Chains:A=19-148
  •   172
    2BQI    Method:X-ray
    Chains:A=19-148
  •   173
    2BQJ    Method:X-ray
    Chains:A=19-148
  •   174
    2BQK    Method:X-ray
    Chains:A=19-147
  •   175
    2BQL    Method:X-ray
    Chains:A=21-148
  •   176
    2BQM    Method:X-ray
    Chains:A=19-148
  •   177
    2BQN    Method:X-ray
    Chains:A=19-148
  •   178
    2BQO    Method:X-ray
    Chains:A=19-148
  •   179
    2HEA    Method:X-ray
    Chains:A=19-148
  •   180
    2HEB    Method:X-ray
    Chains:A=19-148
  •   181
    2HEC    Method:X-ray
    Chains:A=19-148
  •   182
    2HED    Method:X-ray
    Chains:A=19-148
  •   183
    2HEE    Method:X-ray
    Chains:A=19-148
  •   184
    2HEF    Method:X-ray
    Chains:A=19-148
  •   185
    2LHM    Method:X-ray
    Chains:A=19-148
  •   186
    2MEA    Method:X-ray
    Chains:A/B=19-148
  •   187
    2MEB    Method:X-ray
    Chains:A=19-148
  •   188
    2MEC    Method:X-ray
    Chains:A/B=19-148
  •   189
    2MED    Method:X-ray
    Chains:A=19-148
  •   190
    2MEE    Method:X-ray
    Chains:A=19-148
  •   191
    2MEF    Method:X-ray
    Chains:A=19-148
  •   192
    2MEG    Method:X-ray
    Chains:A=19-148
  •   193
    2MEH    Method:X-ray
    Chains:A=19-148
  •   194
    2MEI    Method:X-ray
    Chains:A=19-148
  •   195
    2NWD    Method:X-ray
    Chains:X=19-148
  •   196
    2ZIJ    Method:X-ray
    Chains:A=19-148
  •   197
    2ZIK    Method:X-ray
    Chains:A=19-148
  •   198
    2ZIL    Method:X-ray
    Chains:A=19-148
  •   199
    2ZWB    Method:Neutron
    Chains:A=19-148
  •   200
    3EBA    Method:X-ray
    Chains:B=19-148
  •   201
    3FE0    Method:X-ray
    Chains:A=19-148
  •   202
    3LHM    Method:X-ray
    Chains:A=19-148
  •   203
    3LN2    Method:X-ray
    Chains:A/B=19-148

Sequence

MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRA
TNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRD
PQGIRAWVAWRNRCQNRDVRQYVQGCGV
  BlastP to EnzyBase2

Activity

    No MICs found on enzybiotics database

References

  [1]    The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).  Genome Res.,2004,(14):2121-2127  [PubMed:15489334]
  [2]  Steinrauf L.K.  Structures of monoclinic lysozyme iodide at 1.6 A and of triclinic lysozyme nitrate at 1.1 A.  Acta Crystallogr. D,1998,(54):767-780  [MEDLINE:98437605]
  [3]  Cai L.,Lei X.,Zhao C.,Huang B.,  The cloning, sequencing and analysis of Chinese human lysozyme gene cDNA amplified with RT-PCR from human placental total RNA.  Sheng Wu Hua Hsueh Tsa Chih,1993,(9):269-273  [:]
  [4]  Kikuchi M.,Nokihara K.,Tsunasawa S.,Ishihara K.,Kanaya E.,  Indication of possible post-translational formation of disulphide bonds in the beta-sheet domain of human lysozyme.  Biochem. J.,1993,(292):469-476  [MEDLINE:93277512]
  [5]  Tennent G.A.,Vigushin D.M.,Booth D.R.,Hawkins P.N.,Pepy M.B.,  Human lysozyme gene mutations cause hereditary systemic amyloidosis.  Nature,1993,(362):553-557  [MEDLINE:93218745]
  [6]  Matsushima M.,Morikawa K.,Kikuchi M.,Taniyama Y.,Inaka K.,  The crystal structure of a mutant human lysozyme C77/95A with increased secretion efficiency in yeast.  J. Biol. Chem.,1991,(266):12599-12603  [MEDLINE:91286292]
  [7]  Kikuchi M.,Taniyama Y.,Ohkubo T.,  1H and 15N NMR study of human lysozyme.  J. Biochem.,1991,(110):1022-1029  [MEDLINE:92176149]
  [8]  Dobson C.M.,Redfield C.,  1H NMR studies of human lysozyme: spectral assignment and comparison with hen lysozyme.  Biochemistry,1990,(29):7201-7214  [MEDLINE:91002558]
  [9]  Sippel A.E.,Grzeschik K.H.,Pollwein R.,Kruse U.,Peters C.W.B.,  The human lysozyme gene. Sequence organization and chromosomal localization.  Eur. J. Biochem.,1989,(182):507-516  [MEDLINE:89325294]
  [10]  Sledziewski A.,Chlebowicz-Sledziewska E.,Adolf G.R.,Spevak W.,Castanon M.J.,  Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiae.  Gene,1988,(66):223-234  [MEDLINE:89006264]
  [11]  Gordon S.,Keshav S.,Chung L.P.,  Cloning the human lysozyme cDNA: inverted Alu repeat in the mRNA and in situ hybridization for macrophages and Paneth cells.  Proc. Natl. Acad. Sci. U.S.A.,1988,(85):6227-6231  [MEDLINE:88320415]
  [12]  Nakahama K.,Toibana A.,Yoshimura K.,  Human lysozyme: sequencing of a cDNA, and expression and secretion by Saccharomyces cerevisiae.  Biochem. Biophys. Res. Commun.,1988,(150):794-801  [MEDLINE:88134189]
  [13]  Artymiuk P.J.,Pulford W.C.A.,Blake C.C.F.,  X-ray studies of water in crystals of lysozyme.  J. Mol. Biol.,1983,(167):693-723  [MEDLINE:83268684]
  [14]  Blake C.C.F.,Artymiuk P.J.,  Refinement of human lysozyme at 1.5-A resolution analysis of non-bonded and hydrogen-bond interactions.  J. Mol. Biol.,1981,(152):737-762  [MEDLINE:82145543]
  [15]  Malmquist J.,Brunfeldt K.,Kristiansen K.,Lund E.H.,Thomsen J.,  A Val-Val sequence found in a human monocytic leukemia lysozyme.  FEBS Lett.,1972,(22):34-36  [PubMed:11946554]
  [16]  Jolles P.,Jolles J.,  Comparison between human and bird lysozymes: note concerning the previously observed deletion.  FEBS Lett.,1972,(22):31-33  [PubMed:11946553]
  [17]  Morgan F.J.,Sobel H.H.,Kammerman S.,Canfield R.E.,  Primary structure of lysozymes from man and goose.  Nature New Biol.,1971,(232):16-17  [MEDLINE:71276655]
  [18]  Jolles P.,Jolles J.,  Human milk lysozyme: unpublished data concerning the establishment of the complete primary structure; comparison with lysozymes of various origins.  Helv. Chim. Acta,1971,(54):2668-2675  [MEDLINE:72131416]