Detail of EN76583764


Summary

    Name:LYSC2_ONCMY
    FullName:Lysozyme C II
    Producer Organism:Oncorhynchus mykiss
    Sequence Length:144
    Mass:15737
    Calculated Isoelectric Point:8.57
    Target:Gram-positive bacteria
    Link:P11941
    Function:Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has antibacterial activity against the Gram positive bacterium P.citreus. Has no antibacterial activity against the Gram negative bacteria E.coli and Y.ruckeri. Does not have hemolytic activity against trout erythrocytes.

Domains

InterPro

50
100
144

  1  []:IPR001916,Glyco_hydro_22
  2  []:IPR019799,Glyco_hydro_22_CS
  3  []:IPR000974,Glyco_hydro_22_lys
  4  []:IPR023346,Lysozyme-like_dom

Structures

  •   1
    1BB6    Method:X-ray
    Chains:A=16-144
  •   2
    1BB7    Method:X-ray
    Chains:A=16-144
  •   3
    1LMC    Method:X-ray
    Chains:A=16-144
  •   4
    1LMN    Method:X-ray
    Chains:A=16-144
  •   5
    1LMO    Method:X-ray
    Chains:A=16-144
  •   6
    1LMP    Method:X-ray
    Chains:A=16-144
  •   7
    1LMQ    Method:X-ray
    Chains:A=16-144

Sequence

MRAVVVLLLVAVASAKVYDRCELARALKASGMDGYAGNSLPNWVCLSKWESSYNTQATNR
NTDGSTDYGIFQINSRYWCDDGRTPGAKNVCGIRCSQLLTADLTVAIRCAKRVVLDPNGI
GAWVAWRLHCQNQDLRSYVAGCGV
  BlastP to EnzyBase2

Activity

    No MICs found on enzybiotics database

References

  [1]  Smith V.J.,Kemp G.D.,Fernandes J.M.O.,  Two novel muramidases from skin mucosa of rainbow trout (Oncorhynchus mykiss).  Comp. Biochem. Physiol.,2004,(138):53-64  [PubMed:15142536]
  [2]  Wall R.J.,Rexroad C.E. III,Wells K.D.,Foster-Frey J.,Mitra A.,  Molecular characterization of lysozyme type II gene from rainbow trout (Oncorhynchus mykiss): an evidence of a duplicate gene.  Anim. Biotechnol.,2003,(14):7-12  [PubMed:12887175]
  [3]  Karlsen S.,Hough E.,Vollan V.B.,  Structural studies on the binding of 4-methylumbelliferone glycosides of chitin to rainbow trout lysozyme.  Acta Crystallogr. D,1999,(55):60-66  [MEDLINE:99190830]
  [4]  Riise B.W.,Larsen R.L.,Hansen L.K.,Eliassen B.E.,Karlsen S.,  Refined crystal structure of lysozyme from the rainbow trout (Oncorhynchus mykiss).  Acta Crystallogr. D,1995,(51):354-367  [PubMed:15299303]
  [5]  Pakdel F.,Jolles J.,Pham-Dinh D.,Prager E.M.,Dautingny A.,  cDNA and amino acid sequences of rainbow trout (Oncorhynchus mykiss) lysozymes and their implications for the evolution of lysozyme and lactalbumin.  J. Mol. Evol.,1991,(32):187-198  [MEDLINE:91178823]
  [6]  Jolles P.,Jolles J.,Grinde B.,  Purification and characterization of two lysozymes from rainbow trout (Salmo gairdneri).  Eur. J. Biochem.,1988,(173):269-273  [MEDLINE:88196109]