EnzyBase2: An update of EnzyBase database for enzybiotic studies

Enzybiotics in EnzyBase refer to bacterial cell wall-degrading enzymes including lysins, bacteriocins, autolysins, and lysozymes. The most important characteristics of enzybiotics are a novel mode of antibacterial action, different from those typical of antibiotics, and the capacity to kill antibiotic-resistant bacteria. Another significant feature of some enzybiotics is the low probability of developing bacterial resistance.

1. Distribution of enzybiotics length:

25 enzybiotics with sequence >=0 and sequence <100
178 enzybiotics with sequence >=100 and sequence <200
583 enzybiotics with sequence >=200 and sequence <300
600 enzybiotics with sequence >=300 and sequence <400
367 enzybiotics with sequence >=400 and sequence <500
286 enzybiotics with sequence >=500

2. Distribution of enzybiotics MASS:

184 enzybiotics with (0 K < MASS <=20K)
1100 enzybiotics with (20 K < MASS <=40K)
479 enzybiotics with (40 K < MASS <=60K)
150 enzybiotics with (60 K < MASS <=80K)
97 enzybiotics with (MASS >=80 K)

3. Distribution of enzybiotics pI:

0
1
0
2
1
3
246
4
209
5
283
6
150
7
300
8
448
9
343
10
3
11
0
12
0
13
pI

4. Top 10 domains of enzybiotics:

443 enzybiotics has domain Amidase_domain
224 enzybiotics has domain Glyco_hydro_25
224 enzybiotics has domain Glycoside_hydrolase_SF
218 enzybiotics has domain CHAP
202 enzybiotics has domain Mano_Glyc_endo_b_GlcNAc
183 enzybiotics has domain Glyco_hydro_subgr_catalytic
146 enzybiotics has domain Peptidoglycan-bd_lysin
140 enzybiotics has domain Lysozyme_dom_subfam2
140 enzybiotics has domain Peptidoglycan-bd_Lysin_subgr
139 enzybiotics has domain Glyco_hydro_fam25_subgr

5. Top 10 sources for enzybiotics:

251 enzybiotics originate from
250 enzybiotics originate from Enterococcus faecalis
187 enzybiotics originate from Staphylococcus aureus
146 enzybiotics originate from Bacillus cereus
114 enzybiotics originate from Bacillus thuringiensis
103 enzybiotics originate from Staphylococcus phage
69 enzybiotics originate from Streptococcus pneumoniae
56 enzybiotics originate from Listeria monocytogenes
42 enzybiotics originate from Clostridium perfringens
39 enzybiotics originate from Staphylococcus epidermidis