Drug Summary

  Drug name:  indometacin
  Chemical name:  indomethacin, USP
  Formula:  C₁₉H₁₆ClNO₄
  Weight:   357.788
  CAS no:  53-86-1
  DrugBank link:  DB00328
  Description:  Indomethacin is a non-steroidal antiinflammatory agent (NSAIA) with antiinflammatory, analgesic and antipyretic activity. Its pharmacological effect is thought to be mediated through inhibition of the enzyme cyclooxygenase (COX), the enzyme responsible for catalyzes the rate-limiting step in prostaglandin synthesis via the arachidonic acid pathway.
  Indication:  For moderate to severe rheumatoid arthritis including acute flares of chronic disease, ankylosing spondylitis, osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis.