Drug Summary

  Drug name:  sirolimus
  Chemical name:  rapamycin
  Formula:  C₅₁H₇₉NO₁₃
  Weight:   914.1719
  CAS no:  53123-88-9
  DrugBank link:  DB00877
  Description:  A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. [PubChem]
  Indication:  For the prophylaxis of organ rejection in patients receiving renal transplants.