Drug Summary

  Drug name:  clozapine
  Chemical name:  clozapine
  Formula:  C₁₈H₁₉ClN₄
  Weight:   326.823
  CAS no:  5786-21-0
  DrugBank link:  DB00363
  Description:  A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. [PubChem]
  Indication:  For use in patients with treatment-resistant schizophrenia.