Drug Summary

  Drug name:  baclofen
  Chemical name:  Baclofen (R,S)
  Formula:  C₁₀H₁₂ClNO₂
  Weight:   213.661
  CAS no:  1134-47-0
  DrugBank link:  DB00181
  Description:  Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. Baclofen stimulates GABA-B receptors leading to decreased frequency and amplitude of muscle spasms. It is especially useful in treating muscle spasticity associated with spinal cord injury. It appears to act primarily at the spinal cord level by inhibiting spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways.
  Indication:  For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity.