Drug Summary

  Drug name:  pergolide
  Chemical name:  Pergolide mesylate
  Formula:  C₁₉H₂₆N₂S
  Weight:   314.488
  CAS no:  66104-22-1
  DrugBank link:  DB01186
  Description:  Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson�s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome. It was later found that pergolide increased the risk of cardiac valvulopathy. The drug was withdrawn from the US market in March 2007 and from the Canadian market in August 2007.
  Indication:  Indicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson's disease. It was withdrawn from the US and Canadian markets in 2007 due to an increased risk of cardiac valvulopathy.