Drug Summary

  Drug name:  probenecid
  Chemical name:  Probenecid
  Formula:  C₁₃H₁₉NO₄S
  Weight:   285.359
  CAS no:  57-66-9
  DrugBank link:  DB01032
  Description:  The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. [PubChem]
  Indication:  For the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics.