Drug Summary

  Drug name:  memantine
  Chemical name:  Memantine Hydrochloride
  Formula:  C₁₂H₂₁N
  Weight:   179.3018
  CAS no:  19982-08-2
  DrugBank link:  DB01043
  Description:  Memantine is an amantadine derivative with low to moderate-affinity for NMDA receptors. It is a noncompetitive NMDA receptor antagonist that binds preferentially to NMDA receptor-operated cation channels. It blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction. It is under investigation for the treatment of Alzheimer’s disease, but there has been no clinical support for the prevention or slowing of disease progression.
  Indication:  For the treatment of moderate to severe dementia of the Alzheimer's type.