Drug Summary

  Drug name:  estrone
  Chemical name:  Estrone
  Formula:  C₁₈H₂₂O₂
  Weight:   270.3661
  CAS no:  53-16-7
  DrugBank link:  DB00655
  Description:  Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.
  Indication:  For management of perimenopausal and postmenopausal symptoms.