Drug Summary

  Drug name:  halofantrine
  Chemical name:  Halofantrine hydrochloride
  Formula:  C₂₆H₃₀Cl₂F_{3<
  Weight:   500.424
  CAS no:  69756-53-2
  DrugBank link:  DB01218
  Description:  Halofantrine is a drug used to treat malaria. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme “heme polymerase”), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity.
  Indication:  For treatment of Severe malaria}