Drug Summary

  Drug name:  prednicarbate
  Chemical name:  Prednicarbate
  Formula:  C₂₇H₃₆O₈
  Weight:   488.5699
  CAS no:  73771-04-7
  DrugBank link:  DB01130
  Description:  Prednicarbate is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy. The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin 1-alpha cytokine within keratinocytes. IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and IL-6 synthesis, which are related to skin thickness.
  Indication:  For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.