Currently, in , the tools interface implements two functions for drug repositioning based on two different methods.

Signature based drug repositioning

The signature based drug repositioning function provides an interface to input user’s gene list to compute against DrugSig. After submitting the gene list to DrugSig, user can click the start computing button to compute the scores which is the ratio of the number of common genes between user’s gene list and each gene signature to the number of user’s genes. The results can be accessed later on current submitting page or by searching the task history with user’s email address. The computing result contains queried gene list, drugs produced similar gene list and drugs produced reverse gene list. The similar and reverse gene list can be applied on drug repositioning using 'guilt-by-association’ method and ‘signature reversion’ method respectively.

Target based drug repositioning

The target based drug repositioning function provides an interface to explore the specified target and its targeting drugs, as well as expression of target in cells after treated by drugs. The targeting drugs may have similar indications for drug repurposing. The expression level of target partly reflects the potential of the drug which inhibits or enhances the target.