Record in detail

General Info

lamp_id:L01A000616
Name:AUR21_LITRA
FullName:Aurein-2.1
Source:Litoria raniformis
Mass:1616 Da
Sequence Length:16 aa
Isoelectric Point:9.53
Activity:Antibacterial,Anticancer
Sequence
GLLDIVKKVVGAFGSL
Function:Has antimicrobial activity against B.cereus, L.lactis, L.innocua, M.luteus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure.

Cross-Linking

Cross-linking
1 Database:APD 14
2 Database:CAMP CAMPSQ576
3 Database:DBAASP 1252
4 Database:dbAMP dbAMP_03504
5 Database:DRAMP DRAMP01608
6 Database:SATPdb satpdb12368
7 Database:Uniprot P69016

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000616 From 1 To 16 E-value: 0.003 Score: 31.6
GLLDIVKKVVGAFGSL
2. L12A06192| From 50 To 65 E-value: 0.003 Score: 31.6
GLFDIVKKVVGAFGSL
3. L01A000618 From 1 To 16 E-value: 0.007 Score: 30.4
GLFDIVKKVVGAFGSL
4. L13A026502 From 1 To 15 E-value: 0.008 Score: 30.4
GLLDIVKKVVGAFGS
5. L12A06194| From 50 To 65 E-value: 0.016 Score: 29.3
GLFDIVKKVVGAIGSL

Structure

Domains

Structures

Activity

Antibacterial Activities
1 Target: B.cereus MIC: 50 μg/ml (30.9406 μM)
2 Target: L.lactis MIC: 6 μg/ml (3.71287 μM)
3 Target: L.innocua MIC: 6 μg/ml (3.71287 μM)
4 Target: M.luteus MIC: 100 μg/ml (61.8812 μM)
5 Target: S.epidermidis MIC: 50 μg/ml (30.9406 μM)
6 Target: and S.uberis MIC: 100 μg/ml (61.8812 μM)

Toxicity

Toxicity

Reference

Reference
[1] Carver J.A.,Olver I.N.,Bowie J.H.,Wegener K.L.,Rozek T.,
Title:The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.
Journal:Eur. J. Biochem., 2000, 267, 5330-5341 [MEDLINE:20408845]

Comments

Comments