Record in detail


General Info

  • lamp_id:L01A003082
  • Name:VARA_VIOAR
  • FullName:Varv peptide A
  • Source:Viola arvensis
  • Mass:2902.3 Da
  • Sequence Length:29 aa
  • Isoelectric Point:5.93
  • Activity:Antimicrobial, ,Anticancer,Anticancer
  • Sequence
        GLPVCGETCVGGTCNTPGCSCSWPVCTRN
  • Function:Probably participates in a plant defense mechanism. Has cytotoxic activity against a variety of drug-resistant and drug-sensitive human tumor cell lines, and against primary chronic lymphocytic leukemia cells. Has weak cytotoxic activity against primary ovarian carcinoma cells or normal lymphocytes.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003082    From 1 To 29 E-value: 0.00000000004 Score: 58.5
        GLPVCGETCVGGTCNTPGCSCSWPVCTRN
  • 2. L01A003083    From 1 To 29 E-value: 0.00000000004 Score: 58.2
        GLPICGETCVGGTCNTPGCSCSWPVCTRN
  • 3. L13A023746    From 1 To 29 E-value: 0.00000000006 Score: 57.8
        GLPVCGETCVGGTCNTPGCACSWPVCTRN
  • 4. L13A011671    From 1 To 29 E-value: 0.00000000006 Score: 57.8
        GLPVCGETCVGGTCNTPGCACSWPVCTRN
  • 5. L02A001128    From 1 To 29 E-value: 0.00000000007 Score: 57.8
        GLPVCGETCVGGTCNTPGCTCSWPVCTRN

Structure

  •   Domains
  •   1  Name:Cyclotide    Interpro Link:IPR005535
  •   2  Name:Cyclotide_moebius_CS    Interpro Link:IPR012324
  •   3  Name:Cyclotide_subgr    Interpro Link:IPR017307
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  U-937 GTB lymphoma  IC50:  17.41 μg/ml  (5.99869 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Bohlin L.,Luijendijk T.,Johansson S.,Goeransson U.,Claeson P.,
  •   Title:Fractionation protocol for the isolation of polypeptides from plant biomass.
  •   Journal:J. Nat. Prod., 1998, 61, 77-81  [PubMed:9548831]
  •   [2]  Gullbo J.,Claeson P.,Johansson S.,Goransson U.,Lindholm P.,
  •   Title:Cyclotides: a novel type of cytotoxic agents.
  •   Journal:Mol. Cancer Ther., 2002, 1, 365-369  [PubMed:12477048]
  •   [3]  Larsson R.,Gullbo J.,Hocaoglu Z.,Goransson U.,Svangard E.,
  •   Title:Cytotoxic cyclotides from Viola tricolor.
  •   Journal:J. Nat. Prod., 2004, 67, 144-147  [PubMed:14987049]

Comments

  •   Comments

    •     No comments found on LAMP database



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