Record in detail
General Info
- lamp_id:L01A000002
- Name:D104A_HUMAN
- FullName:Beta-defensin 104
- Source:Homo sapiens
- Mass:5712.5 Da
- Sequence Length:48 aa
- Isoelectric Point:9.45
- Activity:Antibacterial, Antifungal
- Sequence
ELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRKWDESLLNRTKP - Function:Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.
Cross-Linking
- Cross-linking
- 1 Database:dbAMP dbAMP_01443
- 2 Database:Uniprot Q8WTQ1
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000238 From 25 To 72 E-value: 3e-24 Score: 102
ELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRKWDESLLNRTKP - 2. L12A08975| From 25 To 72 E-value: 3e-24 Score: 102
ELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRKWDESLLNRTKP - 3. L12A09171| From 25 To 72 E-value: 4e-24 Score: 101
ELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRKWDESLLNRTKP - 4. L12A08968| From 25 To 72 E-value: 1e-23 Score: 100
ELDRICGYGTARCRKKCRSQEYRIGRCPNTFACCLRKWDESLLNRTKP - 5. L12A10765| From 5 To 52 E-value: 1e-23 Score: 99.8
ELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRKWDESLLNRTKP
Structure
- Domains
No domains found on LAMP database
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
- 1 Target: Staphylococcus carnosus TM300 MIC: 4.5 μg/ml (0.787746 μM)
- 2 Target: Escherichia coli BL21 MIC: 100 μg/ml (17.5055 μM)
- 3 Target: Saccharomyces cerevisiae ATCC9763 MIC: 100 μg/ml (17.5055 μM)
- 4 Target: P. aeruginosa MIC: 4.1 μg/ml (0.717724 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Kluever E.,Rodriguez-Jimenez F.-J.,Schulz S.,Krause A.,Conejo-Garcia J.-R.,
- Title:Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity.
- Journal:FASEB J., 2001, 15, 1819-1821 [PubMed:11481241]
- [2]
- Title:The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
- Journal:Genome Res., 2004, 14, 2121-2127 [PubMed:15489334]
Comments
- Comments
No comments found on LAMP database