Record in detail


General Info

  • lamp_id:L01A000009
  • Name:DEF_VIGUS
  • FullName:Defensin-like protein
  • Source:Vigna unguiculata subsp. sesquipedalis
  • Mass:1157.2 Da
  • Sequence Length:10 aa
  • Isoelectric Point:4.19
  • Activity:Antibacterial, Antifungal, Antiviral,Anticancer
  • Sequence
        KTCENLADTY
  • Function:Has antifungal activity against F.oxysporum, B.cinera and M.arachidicola with IC(50) values of 1.4 uM, 2.5 uM and 0.15 uM, respectively. Has antibacterial activity against the Gram-positive bacteria B.megaterium, B.subtilis and M.phlei, and the Gram-negative bacterium P.vulgaris. No antibacterial activity against the Gram-positive bacteria B.cereus and S.aureus, or the Gram-negative bacteria E.coli, E.aerogenes, P.aeruginosa and P.fluorescens. Has mitogenic activity towards murine splenocytes. Inhibits the proliferation of M1 leukemia and MCF-7 breast cancer cells in vitro. Inhibits human immunodeficiency virus-1 (HIV-1) reverse transcriptase.

Cross-Linking

  •   Cross-linking
  •   1  Database:APD  553
  •   2  Database:CAMP  CAMPSQ7
  •   3  Database:DBAASP  500
  •   4  Database:dbAMP  dbAMP_05378
  •   5  Database:DRAMP  DRAMP00409
  •   6  Database:SATPdb  satpdb24206
  •   7  Database:Uniprot  P84868

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L11A002570    From 29 To 38 E-value: 0.32 Score: 24.3
        KTCENLADTY
  • 2. L01A000009    From 1 To 10 E-value: 0.33 Score: 24.3
        KTCENLADTY
  • 3. L02A001677    From 1 To 10 E-value: 0.36 Score: 24.3
        KTCENLADTY
  • 4. L07APD0118    From 1 To 10 E-value: 0.39 Score: 23.9
        KTCENLADTY
  • 5. L07APD0170    From 1 To 10 E-value: 0.39 Score: 23.9
        KTCENLADTY

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  Botrytis cinerea  IC50:  2.89 μg/ml  (2.49741 μM)  
  •   2  Target:  Fusarium oxysporum  IC50:  1.62 μg/ml  (1.39993 μM)  
  •   3  Target:  Mycosphaerella arachidicola  IC50:  0.17 μg/ml  (0.146906 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Ng T.B.,Wong J.H.,
  •   Title:Sesquin, a potent defensin-like antimicrobial peptide from ground beans with inhibitory activities toward tumor cells and HIV-1 reverse transcriptase.
  •   Journal:Peptides, 2005, 26, 1120-1126  [PubMed:15949629]

Comments

  •   Comments

    •     No comments found on LAMP database



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