Record in detail


General Info

  • lamp_id:L01A000010
  • Name:DFB11_BOVIN
  • FullName:Beta-defensin 11
  • Source:Bos taurus
  • Mass:4163 Da
  • Sequence Length:38 aa
  • Isoelectric Point:10.09
  • Activity:Antibacterial
  • Sequence
        GPLSCRRNGGVCIPIRCPGPMRQIGTCFGRPVKCCRSW
  • Function:Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A09080|    From 23 To 60 E-value: 2e-17 Score: 79.7
        GPLSCRRNGGVCIPIRCPGPMRQIGTCFGRPVKCCRSW
  • 2. L12A02357|    From 7 To 44 E-value: 9e-17 Score: 77.4
        GPLSCRRNGGVCIPIRCPGPMRQIGTCFGRPVKCCRSW
  • 3. L01A000010    From 1 To 38 E-value: 1e-16 Score: 76.6
        GPLSCRRNGGVCIPIRCPGPMRQIGTCFGRPVKCCRSW
  • 4. L03A000070    From 16 To 53 E-value: 0.000000000000001 Score: 73.9
        GPLSCRRKGGICILIRCPGPMRQIGTCFGRPVKCCRSW
  • 5. L03A000261    From 23 To 60 E-value: 0.000000000000002 Score: 72.8
        GPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW

Structure

  •   Domains
  •   1  Name:Defensin_beta-typ    Interpro Link:IPR001855
  •   2  Name:Defensin_beta/neutrophil    Interpro Link:IPR006080
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  S. aureus  MIC:  10 μg/ml  (2.40211 μM)  
  •   2  Target:  E. coli  MIC:  10 μg/ml  (2.40211 μM)  

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Novotny M.J.,McGuire P.A.,Morris W.L.,Tang Y.-Q.,Selsted M.E.,
  •   Title:Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.
  •   Journal:J. Biol. Chem., 1993, 268, 6641-6648  [MEDLINE:93203264]
  •   [2]  Kalm E.,Schroder J.M.,Paul S.,Exner K.,Roosen S.,
  •   Title:Bovine beta-defensins: identification and characterization of novel bovine beta-defensin genes and their expression in mammary gland tissue.
  •   Journal:Mamm. Genome, 2004, 15, 834-842  [PubMed:15520886]

Comments

  •   Comments

  •     No comments found on LAMP database



CAPTCHA Image   Reload Image
Enter Code*: