Record in detail

General Info

lamp_id:L01A000018
Name:MASTB_VESMG
FullName:Mastoparan-like peptide 12b
Source:Vespa magnifica
Mass:1485.9 Da
Sequence Length:13 aa
Isoelectric Point:11.1
Activity:Antibacterial, Antifungal
Sequence
INWKGIAAMKKLL
Function:Mast cell degranulating peptide. Has little hemolytic activity. Shows antimicrobial activity against the Gram-negative bacteria E.coli ATCC 25922 (MIC=15 ug/ml), the Gram-positive bacteria S.aureus ATCC 2592 (MIC=3.7 ug/ml) and the fungus C.albicans ATCC 2002 (MIC=7.5 ug/ml).

Cross-Linking

Cross-linking
1 Database:CAMP CAMPSQ16
2 Database:DBAASP 1563
3 Database:dbAMP dbAMP_04812
4 Database:DRAMP DRAMP03034
5 Database:SATPdb satpdb23270
6 Database:Uniprot P0C1M5

Top similar AMPs

Top similar AMPs on LAMP
1. L01A000018 From 1 To 13 E-value: 0.037 Score: 27.7
INWKGIAAMKKLL
2. L13A012632 From 1 To 12 E-value: 0.1 Score: 26.2
INWKGIAAMKKL
3. L11A012969 From 1 To 13 E-value: 0.76 Score: 23.5
INWKGIAAMAKKL
4. L13A024089 From 1 To 13 E-value: 0.82 Score: 23.5
INWKGIAAMAKKL
5. L11A012973 From 1 To 13 E-value: 0.82 Score: 23.5
INWKGIAAMAKKL

Structure

Domains

Structures

Activity

Antibacterial Activities
1 Target: E. coli ATCC 25922 MIC: 15 μg/ml (10.0949 μM)
2 Target: S. aureus ATCC 2592 MIC: 3.7 μg/ml (2.49007 μM)
3 Target: C. albicans ATCC 2002 MIC: 7.5 μg/ml (5.04745 μM)

Toxicity

Toxicity

Reference

Reference
[1] Lai R.,Li J.,Yu H.,Yang H.,Xu X.,
Title:The mastoparanogen from wasp.
Journal:Peptides, 2006, 27, 3053-3057 [PubMed:17046111]
[2] Zhang Y.,Yang H.,Lu Q.,Li J.,Xu X.,
Title:Two families of antimicrobial peptides from wasp (Vespa magnifica) venom.
Journal:Toxicon, 2006, 47, 249-253 [PubMed:16330062]

Comments

Comments