Record in detail


General Info

  • lamp_id:L01A000027
  • Name:MASTI_POLPI
  • FullName:Mastoparan-1
  • Source:Polybia paulista
  • Mass:1655 Da
  • Sequence Length:14 aa
  • Isoelectric Point:9.45
  • Activity:Antibacterial,Anticancer
  • Sequence
        IDWKKLLDAAKQIL
  • Function:Chemotactic peptide for polymorphonucleated leukocytes (PMNL), but causing no hemolysis to rat erythrocytes and no mast cell degranulation activity at physiological concentrations. Potent antimicrobial peptide against Gram-positive bacteria B.subtilis CCT 2576 (MIC=4 ug/ml), and S.aureus ATCC 6538 (MIC=15 ug/ml) and Gram-negative bacteria E.coli ATCC 25922 (MIC=8 ug/ml) and P.aeruginosa ATCC 15422 (MIC=8 ug/ml).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000027    From 1 To 14 E-value: 0.018 Score: 28.9
        IDWKKLLDAAKQIL
  • 2. L13A025722    From 1 To 14 E-value: 0.042 Score: 27.7
        INWKKLLDAAKQIL
  • 3. L13A024477    From 1 To 14 E-value: 0.042 Score: 27.7
        INWKKLLDAAKQIL
  • 4. L13A026615    From 1 To 13 E-value: 0.049 Score: 27.3
        IDWKKLLDAAKQI
  • 5. L11A012401    From 1 To 14 E-value: 0.23 Score: 25.4
        IDWKKXLDAXKQIL

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  B. subtilis CCT 2576  MIC:  4 μg/ml  (2.41692 μM)  
  •   2  Target:  S. aureus ATCC 6538  MIC:  15 μg/ml  (9.06344 μM)  
  •   3  Target:  E. coli ATCC 25922  MIC:  8 μg/ml  (4.83384 μM)  
  •   4  Target:  P. aeruginosa ATCC 15422  MIC:  8 μg/ml  (4.83384 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Cesar L.M.M.,Marques M.R.,Santos L.D.,Mendes M.A.,Souza B.M.,
  •   Title:Structural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista.
  •   Journal:Peptides, 2005, 26, 2157-2164  [PubMed:16129513]

Comments

  •   Comments

    •     No comments found on LAMP database



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