Record in detail


General Info

  • lamp_id:L01A000028
  • Name:PROTO_POLPI
  • FullName:Polybia-CP
  • Source:Polybia paulista
  • Mass:1240.6 Da
  • Sequence Length:12 aa
  • Isoelectric Point:9.69
  • Activity:Antibacterial
  • Sequence
        ILGTILGLLKSL
  • Function:Chemotactic peptide for polymorphonucleated leukocytes (PMNL), but causing a very reduced hemolysis to rat erythrocytes and no mast cell degranulation activity at physiological concentrations. Potent antimicrobial peptide against Gram-positive bacteria B.subtilis CCT 2576 (MIC=15 ug/ml), and S.aureus ATCC 6538 (MIC=15 ug/ml). Has no antimicrobial activity against Gram-negative bacteria E.coli ATCC 25922 (MIC=250 ug/ml) and P.aeruginosa ATCC 15422 (MIC=250 ug/ml).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000028    From 1 To 12 E-value: 1.3 Score: 22.3
        ILGTILGLLKSL
  • 2. L13A015079    From 1 To 11 E-value: 2.7 Score: 21.6
        ILGTILGLLKS
  • 3. L01A000598    From 1 To 12 E-value: 4.9 Score: 20.8
        ILGTILGLLKGL
  • 4. L13A021437    From 1 To 11 E-value: 9.8 Score: 19.6
        ILGTILGLLKG

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  B. subtilis CCT 2576  MIC:  15 μg/ml  (12.0909 μM)  
  •   2  Target:  S. aureus ATCC 6538  MIC:  15 μg/ml  (12.0909 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Cesar L.M.M.,Marques M.R.,Santos L.D.,Mendes M.A.,Souza B.M.,
  •   Title:Structural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista.
  •   Journal:Peptides, 2005, 26, 2157-2164  [PubMed:16129513]

Comments

  •   Comments

    •     No comments found on LAMP database



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