Record in detail


General Info

  • lamp_id:L01A000038
  • Name:DMS1_PHYHY
  • FullName:Dermaseptin-1
  • Source:Phyllomedusa hypochondrialis
  • Mass:2410.8 Da
  • Sequence Length:25 aa
  • Isoelectric Point:10.51
  • Activity:Antibacterial, Antiparasitic
  • Sequence
        GLWSTIKNVGKEAAIAAGKAALGAL
  • Function:Has antibacterial activity against the Gram-negative bacteria E.coli and P.aeruginosa, and the Gram-positive bacteria S.aureus and M.luteus. Has antiprotozoal activity against L.amazonensis. No hemolytic activity.

Cross-Linking

  •   Cross-linking
  •   1  Database:APD  763
  •   2  Database:APD  944
  •   3  Database:APD  952
  •   4  Database:CAMP  CAMPSQ1060
  •   5  Database:DBAASP  1546
  •   6  Database:dbAMP  dbAMP_03856
  •   7  Database:DRAMP  DRAMP01639
  •   8  Database:SATPdb  satpdb11818
  •   9  Database:Uniprot  P84596

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A06203|    From 46 To 70 E-value: 0.00000002 Score: 49.7
        GLWSTIKNVGKEAAIAAGKAALGAL
  • 2. L12A06199|    From 46 To 70 E-value: 0.00000002 Score: 49.7
        GLWSTIKNVGKEAAIAAGKAALGAL
  • 3. L12A06174|    From 46 To 70 E-value: 0.00000002 Score: 49.3
        GLWSTIKNVGKEAAIAAGKAALGAL
  • 4. L02A001351    From 1 To 25 E-value: 0.00000009 Score: 47.4
        GLWSTIKNVGKEAAIAAGKAALGAL
  • 5. L01A000038    From 1 To 25 E-value: 0.0000001 Score: 47.4
        GLWSTIKNVGKEAAIAAGKAALGAL

Structure

  •   Domains
  •   1  Name:Brevinin    Interpro Link:IPR004275
  •   2  Name:Dermaseptin    Interpro Link:IPR022731
  •   3  Name:Dermaseptin_precursor    Interpro Link:IPR016322
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  M. luteus  MIC:  14.46 μg/ml  (5.99801 μM)  
  •   2  Target:  S. aureus  MIC:  14.46 μg/ml  (5.99801 μM)  
  •   3  Target:  E. coli  MIC:  14.46 μg/ml  (5.99801 μM)  
  •   4  Target:  P. aeruginosa  MIC:  14.46 μg/ml  (5.99801 μM)  
  •   5  Target:  E. coli  MIC:  1.92864 μg/ml  (0.8 μM)  
  •   6  Target:  S. aureus  MIC:  0.96432 μg/ml  (0.4 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Jared C.,Antoniazzi M.M.,Richardson M.,Konno K.,Conceicao K.,
  •   Title:Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis.
  •   Journal:Peptides, 2006, 27, 3092-3099  [PubMed:16963159]
  •   [2]  Silva L.P.,Mesquita D.A.,de Sa Mandel S.M.,Leite J.R.S.A.,Brand G.D.,
  •   Title:Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia).
  •   Journal:Biochem. Biophys. Res. Commun., 2006, 347, 739-746  [PubMed:16844081]

Comments

  •   Comments

    •     No comments found on LAMP database



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