Record in detail


General Info

  • lamp_id:L01A000041
  • Name:BMNL1_BOMOR
  • FullName:Bombinin-like peptides 1
  • Source:Bombina orientalis
  • Mass:2582 Da
  • Sequence Length:27 aa
  • Isoelectric Point:10.51
  • Activity:Antibacterial
  • Sequence
        GIGASILSAGKSALKGLAKGLAEHFAN
  • Function:Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria.

Cross-Linking

  •   Cross-linking
  •   1  Database:APD  50
  •   2  Database:CAMP  CAMPSQ38
  •   3  Database:DBAASP  529
  •   4  Database:dbAMP  dbAMP_02892
  •   5  Database:DRAMP  DRAMP01097
  •   6  Database:SATPdb  satpdb24243
  •   7  Database:Uniprot  P29002

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000041    From 1 To 27 E-value: 0.000000008 Score: 50.8
        GIGASILSAGKSALKGLAKGLAEHFAN
  • 2. L01A000231    From 1 To 27 E-value: 0.00000002 Score: 49.7
        GIGASILSAGKSALKGFAKGLAEHFAN
  • 3. L01A000042    From 1 To 27 E-value: 0.00000004 Score: 48.5
        GIGSAILSAGKSALKGLAKGLAEHFAN
  • 4. L01A000004    From 1 To 27 E-value: 0.0000001 Score: 46.6
        GIGGALLSAGKSALKGLAKGLAEHFAN
  • 5. L01A000043    From 1 To 25 E-value: 0.0000003 Score: 45.8
        GIGAAILSAGKSALKGLAKGLAEHF

Structure

  •   Domains
  •   1  Name:Bombinin    Interpro Link:IPR007962
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  82 % inhibition Neisseria meningitidis 118V C  MIC:  20 μg/ml  (7.74593 μM)  
  •   2  Target:  98 % inhibition Neisseria meningitidis 15240 IAI  MIC:  20 μg/ml  (7.74593 μM)  
  •   3  Target:  85% inhibition Neisseria meningitidis 126E IC1  MIC:  20 μg/ml  (7.74593 μM)  
  •   4  Target:  96% inhibition Neisseria Iactamica 15323  MIC:  20 μg/ml  (7.74593 μM)  
  •   5  Target:  100% inhibition Neisseria Iactamica 15215A  MIC:  20 μg/ml  (7.74593 μM)  
  •   6  Target:  98% inhibition Neisseria cinerea 15461  MIC:  20 μg/ml  (7.74593 μM)  
  •   7  Target:  Bacillus megaterium BmII  MIC:  0.77 μg/ml  (0.298218 μM)  
  •   8  Target:  Staphylococcus aureus Cowan1  MIC:  8.78 μg/ml  (3.40046 μM)  
  •   9  Target:  Escherichia coli D21  MIC:  4.39 μg/ml  (1.70023 μM)  
  •   10  Target:  Escherichia coli D22  MIC:  3.87 μg/ml  (1.49884 μM)  
  •   11  Target:  Yersinia pseudotubercolosis  MIC:  2.07 μg/ml  (0.801704 μM)  
  •   12  Target:  Pseudomonas aeruginosa ATCC 15692  MIC:  16.27 μg/ml  (6.30132 μM)  
  •   13  Target:  Candida albicans  MIC:  1.03 μg/ml  (0.398916 μM)  
  •   14  Target:  E. coli  MIC:  3.873 μg/ml  (1.5 μM)  
  •   15  Target:  S. aureus  MIC:  8.7788 μg/ml  (3.4 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Spindel E.R.,Kelly M.,Mandrell R.,Tang D.,Gibson B.W.,
  •   Title:Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis.
  •   Journal:J. Biol. Chem., 1991, 266, 23103-23111  [MEDLINE:92078177]

Comments

  •   Comments

    •     No comments found on LAMP database



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