Record in detail


General Info

  • lamp_id:L01A000043
  • Name:BMNL3_BOMOR
  • FullName:Bombinin-like peptides 3
  • Source:Bombina orientalis
  • Mass:2380.8 Da
  • Sequence Length:25 aa
  • Isoelectric Point:10.51
  • Activity:Antibacterial
  • Sequence
        GIGAAILSAGKSALKGLAKGLAEHF
  • Function:Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria.

Cross-Linking

  •   Cross-linking
  •   1  Database:APD  52
  •   2  Database:CAMP  CAMPSQ40
  •   3  Database:DBAASP  534
  •   4  Database:dbAMP  dbAMP_02881
  •   5  Database:DRAMP  DRAMP01098
  •   6  Database:SATPdb  satpdb18454
  •   7  Database:Uniprot  P29004

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000043    From 1 To 25 E-value: 0.0000002 Score: 46.6
        GIGAAILSAGKSALKGLAKGLAEHF
  • 2. L01A000042    From 1 To 25 E-value: 0.0000003 Score: 45.8
        GIGSAILSAGKSALKGLAKGLAEHF
  • 3. L01A000041    From 1 To 25 E-value: 0.0000003 Score: 45.8
        GIGASILSAGKSALKGLAKGLAEHF
  • 4. L13A024592    From 1 To 25 E-value: 0.0000005 Score: 44.7
        GIGGAILSAGKSALKGLAKGLAEHF
  • 5. L01A000231    From 1 To 25 E-value: 0.0000006 Score: 44.7
        GIGASILSAGKSALKGFAKGLAEHF

Structure

  •   Domains
  •   1  Name:Bombinin    Interpro Link:IPR007962
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  59 % inhibition Neisseria meningitidis 118V C  MIC:  20 μg/ml  (8.40054 μM)  
  •   2  Target:  99 % inhibition Neisseria meningitidis 15240 IAI  MIC:  20 μg/ml  (8.40054 μM)  
  •   3  Target:  99% inhibition Neisseria meningitidis 126E IC1  MIC:  20 μg/ml  (8.40054 μM)  
  •   4  Target:  99% inhibition Neisseria gonorrhoeoe F62  MIC:  20 μg/ml  (8.40054 μM)  
  •   5  Target:  97% inhibitionNeisseria Iactamica 15323  MIC:  20 μg/ml  (8.40054 μM)  
  •   6  Target:  100% inhibition Neisseria Iactamica 15215A  MIC:  20 μg/ml  (8.40054 μM)  
  •   7  Target:  97% inhibition Neisseria cinerea 15461  MIC:  20 μg/ml  (8.40054 μM)  
  •   8  Target:  Bacillus megaterium BmII ( MIC = 0.3 �M Staphylo  MIC:  0.95 μg/ml  (0.399026 μM)  
  •   9  Target:  E. coli  MIC:  2.14272 μg/ml  (0.9 μM)  
  •   10  Target:  S. aureus  MIC:  4.04736 μg/ml  (1.7 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Spindel E.R.,Kelly M.,Mandrell R.,Tang D.,Gibson B.W.,
  •   Title:Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis.
  •   Journal:J. Biol. Chem., 1991, 266, 23103-23111  [MEDLINE:92078177]
  •   [2]  Simmaco M.,Barra D.,Boman H.G.,Ponti D.,Miele R.,
  •   Title:Molecular cloning of a bombinin gene from Bombina orientalis: detection of NF-kappaB and NF-IL6 binding sites in its promoter.
  •   Journal:FEBS Lett., 1998, 431, 23-28  [MEDLINE:98348000]

Comments

  •   Comments

    •     No comments found on LAMP database



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