Record in detail


General Info

  • lamp_id:L01A000047
  • Name:LAT2A_LACTA
  • FullName:M-zodatoxin-Lt2a
  • Source:Lachesana tarabaevi
  • Mass:2902.6 Da
  • Sequence Length:26 aa
  • Isoelectric Point:11.97
  • Activity:Antibacterial, Antifungal
  • Sequence
        GLFGKLIKKFGRKAISYAVKKARGKH
  • Function:It has antimicrobial activity against Gram-positive bacteria (A.globiformis VKM Ac-1112 (MIC=0.7 ug/ml), and B.subtilis VKM B-501 (MIC=0.4 ug/ml)), Gram-negative bacteria (E.coli DH5-alpha (MIC=1.0 ug/ml), E.coli MH1 (MIC=0.7 ug/ml), and P.aeruginosa PAO1 (MIC=6.7 ug/ml)), and yeasts (P.pastoris GS115 (MIC=6.7 ug/ml), and S.cerevisiae Y190 (MIC=54 ug/ml)). Also has a strong hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A08392|    From 59 To 84 E-value: 0.000000001 Score: 53.5
        GLFGKLIKKFGRKAISYAVKKARGKH
  • 2. L01A000047    From 1 To 26 E-value: 0.00000001 Score: 50.4
        GLFGKLIKKFGRKAISYAVKKARGKH
  • 3. L13A023171    From 1 To 26 E-value: 0.00000004 Score: 48.5
        GLFGKLIKKFARKAISYAVKKARGKH
  • 4. L01A000048    From 1 To 26 E-value: 0.00000005 Score: 48.1
        GLFGKLIKKFGRKAISYAVKKARGKN
  • 5. L13A014628    From 1 To 26 E-value: 0.00000007 Score: 47.8
        GLFGKLQKKFGRKAISYAVKKARGKH

Structure

  •   Domains
  •   1  Name:Latarcin_precursor    Interpro Link:IPR018802
  •   Structures

Activity

  •   Antibacterial Activities
  •   1  Target:  A. globiformis VKM Ac-1112  MIC:  2.03 μg/ml  (0.699373 μM)  
  •   2  Target:  B. subtilis VKM B-501  MIC:  1.16 μg/ml  (0.399642 μM)  
  •   3  Target:  E. coli DH5-alpha  MIC:  2.9 μg/ml  (0.999104 μM)  
  •   4  Target:  E. coli MH1  MIC:  2.03 μg/ml  (0.699373 μM)  
  •   5  Target:  P. aeruginosa PAO1  MIC:  19.45 μg/ml  (6.70089 μM)  
  •   6  Target:  P. pastoris GS115  MIC:  19.45 μg/ml  (6.70089 μM)  
  •   7  Target:  S. cerevisiae Y190  MIC:  156.74 μg/ml  (53.9999 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Karpunin D.V.,Surovoy A.Y.,Feofanov A.V.,Vassilevski A.A.,Kozlov S.A.,
  •   Title:Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.
  •   Journal:J. Biol. Chem., 2006, 281, 20983-20992  [PubMed:16735513]
  •   [2]  Efremov R.G.,Chupin V.V.,Polyansky A.A.,Volynsky P.E.,Dubovskii P.V.,
  •   Title:Spatial structure and activity mechanism of a novel spider antimicrobial peptide.
  •   Journal:Biochemistry, 2006, 45, 10759-10767  [PubMed:16939228]

Comments

  •   Comments

    •     No comments found on LAMP database



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