Record in detail


General Info

  • lamp_id:L01A000049
  • Name:LAT3A_LACTA
  • FullName:M-zodatoxin-Lt3a
  • Source:Lachesana tarabaevi
  • Mass:2484 Da
  • Sequence Length:20 aa
  • Isoelectric Point:10.84
  • Activity:Antibacterial, Antifungal
  • Sequence
        SWKSMAKKLKEYMEKLKQRA
  • Function:It has antimicrobial activity against Gram-positive bacteria (A.globiformis VKM Ac-1112 (MIC=0.3 ug/ml), and B.subtilis VKM B-501 (MIC=1.2 ug/ml)), Gram-negative bacteria (E.coli DH5-alpha (MIC=2.5 ug/ml), E.coli MH1 (MIC=6.0 ug/ml), and P.aeruginosa PAO1 (MIC>40 ug/ml)), and yeasts (P.pastoris GS115 (MIC=20 ug/ml), and S.cerevisiae Y190 (MIC=20 ug/ml)). Does not have hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A08356|    From 62 To 81 E-value: 0.000004 Score: 41.6
        SWKSMAKKLKEYMEKLKQRA
  • 2. L01A000049    From 1 To 20 E-value: 0.00001 Score: 39.7
        SWKSMAKKLKEYMEKLKQRA
  • 3. L12A08355|    From 62 To 81 E-value: 0.00002 Score: 39.3
        SWASMAKKLKEYMEKLKQRA
  • 4. L01A000050    From 1 To 20 E-value: 0.00004 Score: 38.1
        SWASMAKKLKEYMEKLKQRA
  • 5. L01A002277    From 58 To 76 E-value: 2.6 Score: 22.3
        WKGVGAKMSERVEKLSQKA

Structure

  •   Domains
  •   1  Name:Latarcin_precursor    Interpro Link:IPR018802
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  A. globiformis VKM Ac-1112  MIC:  0.75 μg/ml  (0.301932 μM)  
  •   2  Target:  B. subtilis VKM B-501  MIC:  2.98 μg/ml  (1.19968 μM)  
  •   3  Target:  E.coli DH5-alpha  MIC:  6.21 μg/ml  (2.5 μM)  
  •   4  Target:  E. coli MH1  MIC:  14.9 μg/ml  (5.99839 μM)  
  •   5  Target:  P.aeruginosa PAO1  MIC:  99.36 μg/ml  (40 μM)  
  •   6  Target:  P. pastoris GS115  MIC:  49.68 μg/ml  (20 μM)  
  •   7  Target:  S.cerevisiae Y190  MIC:  49.68 μg/ml  (20 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Karpunin D.V.,Surovoy A.Y.,Feofanov A.V.,Vassilevski A.A.,Kozlov S.A.,
  •   Title:Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.
  •   Journal:J. Biol. Chem., 2006, 281, 20983-20992  [PubMed:16735513]

Comments

  •   Comments

    •     No comments found on LAMP database



CAPTCHA Image   Reload Image
Enter Code*: