Record in detail
General Info
- lamp_id:L01A000050
- Name:LAT3B_LACTA
- FullName:M-zodatoxin-Lt3b
- Source:Lachesana tarabaevi
- Mass:2426.9 Da
- Sequence Length:20 aa
- Isoelectric Point:10.69
- Activity:Antibacterial, Antifungal
- Sequence
SWASMAKKLKEYMEKLKQRA - Function:It has antimicrobial activity against Gram-positive bacteria (A.globiformis VKM Ac-1112 (MIC=0.7 ug/ml), and B.subtilis VKM B-501 (MIC=2.9 ug/ml)), Gram-negative bacteria (E.coli DH5-alpha (MIC=23 ug/ml), E.coli MH1 (MIC=28 ug/ml), and P.aeruginosa PAO1 (MIC>45 ug/ml)), and yeasts (P.pastoris GS115 (MIC=23 ug/ml), and S.cerevisiae Y190 (MIC=23 ug/ml)). Does not have hemolytic against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.
Cross-Linking
- Cross-linking
- 1 Database:APD 1013
- 2 Database:CAMP CAMPSQ46
- 3 Database:DBAASP 557
- 4 Database:dbAMP dbAMP_11304
- 5 Database:DRAMP DRAMP03230
- 6 Database:SATPdb satpdb19943
- 7 Database:Uniprot Q1ELU2
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L12A08355| From 62 To 81 E-value: 0.000003 Score: 42
SWASMAKKLKEYMEKLKQRA - 2. L01A000050 From 1 To 20 E-value: 0.00001 Score: 40
SWASMAKKLKEYMEKLKQRA - 3. L12A08356| From 62 To 81 E-value: 0.00002 Score: 38.9
SWKSMAKKLKEYMEKLKQRA - 4. L01A000049 From 1 To 20 E-value: 0.00004 Score: 38.1
SWKSMAKKLKEYMEKLKQRA
Structure
- Domains
- 1 Name:Latarcin_precursor Interpro Link:IPR018802
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
- 1 Target: A. globiformis VKM Ac-1112 MIC: 1.7 μg/ml (0.700482 μM)
- 2 Target: B. subtilis VKM B-501 MIC: 7.04 μg/ml (2.90082 μM)
- 3 Target: E. coli DH5-alpha MIC: 55.82 μg/ml (23.0005 μM)
- 4 Target: E. coli MH1 MIC: 67.95 μg/ml (27.9987 μM)
- 5 Target: P. aeruginosa PAO1 MIC: 109.21 μg/ml (44.9998 μM)
- 6 Target: P. pastoris GS115 MIC: 55.82 μg/ml (23.0005 μM)
- 7 Target: S. cerevisiae Y190 MIC: 55.82 μg/ml (23.0005 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Karpunin D.V.,Surovoy A.Y.,Feofanov A.V.,Vassilevski A.A.,Kozlov S.A.,
- Title:Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.
- Journal:J. Biol. Chem., 2006, 281, 20983-20992 [PubMed:16735513]
Comments
- Comments
No comments found on LAMP database