Record in detail

lamp_id:L01A000052
Name:LAT4B_LACTA
FullName:M-zodatoxin-Lt4b
Source:Lachesana tarabaevi
Mass:2885.5 Da
Sequence Length:24 aa
Isoelectric Point:10.72
Activity:Antibacterial, Antifungal
Sequence
SLKDKVKSMGEKLKQYIQTWKAKF
Function:Has antimicrobial activity against Gram-positive bacteria (A.globiformis VKM Ac-1112 (MIC=0.3 ug/ml), and B.subtilis VKM B-501 (MIC=1.1 ug/ml)), Gram-negative bacteria (E.coli DH5-alpha (MIC=4.4 ug/ml), E.coli MH1 (MIC=4.4 ug/ml), and P.aeruginosa PAO1 (MIC=>35 ug/ml)), and yeasts (P.pastoris GS115 (MIC=>35 ug/ml), and S.cerevisiae Y190 (MIC=35 ug/ml)). Does not have hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.

Top similar AMPs on LAMP
1. L01A000052 From 1 To 24 E-value: 0.00000003 Score: 49.3
SLKDKVKSMGEKLKQYIQTWKAKF
2. L01A000003 From 1 To 24 E-value: 0.0000003 Score: 45.4
GLKDKFKSMGEKLKQYIQTWKAKF

Antibacterial Activities
1 Target: A. globiformis VKM Ac-1112 MIC: 0.87 μg/ml (0.301508 μM)
2 Target: B. subtilis VKM B-501 MIC: 3.17 μg/ml (1.0986 μM)
3 Target: E. coli DH5-alpha MIC: 12.7 μg/ml (4.40132 μM)
4 Target: E. coli MH1 MIC: 12.7 μg/ml (4.40132 μM)
5 Target: P. aeruginosa PAO1 MIC: 100.99 μg/ml (34.9991 μM)
6 Target: P. pastoris GS115 MIC: 100.99 μg/ml (34.9991 μM)
7 Target: S. cerevisiae Y190 MIC: 100.99 μg/ml (34.9991 μM)

Reference
[1] Karpunin D.V.,Surovoy A.Y.,Feofanov A.V.,Vassilevski A.A.,Kozlov S.A.,
Title:Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.
Journal:J. Biol. Chem., 2006, 281, 20983-20992 [PubMed:16735513]