Record in detail

lamp_id:L01A000053
Name:LAT5_LACTA
FullName:M-zodatoxin-Lt5a
Source:Lachesana tarabaevi
Mass:3431.1 Da
Sequence Length:28 aa
Isoelectric Point:11.87
Activity:Antibacterial, Antifungal
Sequence
GFFGKMKEYFKKFGASFKRRFANLKKRL
Function:Has antimicrobial activity against. Gram-positive bacteria (A.globiformis VKM Ac-1112 (MIC=1.1 ug/ml), and B.subtilis VKM B-501 (MIC=0.6 ug/ml)), Gram-negative bacteria (E.coli DH5-alpha (MIC=0.6 ug/ml), E.coli MH1 (MIC=0.6 ug/ml), and P.aeruginosa PAO1 (MIC=18 ug/ml)), and yeasts (P.pastoris GS115 (MIC>37 ug/ml), and S.cerevisiae Y190 (MIC>37 ug/ml)). Also has a moderate hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.

Top similar AMPs on LAMP
1. L12A08391| From 65 To 92 E-value: 0.0000000001 Score: 57
GFFGKMKEYFKKFGASFKRRFANLKKRL
2. L01A000053 From 1 To 28 E-value: 0.000000001 Score: 53.5
GFFGKMKEYFKKFGASFKRRFANLKKRL
3. L13A015911 From 1 To 27 E-value: 0.000000005 Score: 51.6
GFFGKMKEYFKKFGASFKRRFANLKKR
4. L13A013446 From 1 To 28 E-value: 0.00000001 Score: 50.4
GFFGKRKEYFKKFGASFKRRFANLKKRL
5. L13A020139 From 1 To 25 E-value: 0.00000005 Score: 48.1
GKMKEYFKKFGASFKRRFANLKKRL

Antibacterial Activities
1 Target: A. globiformis VKM Ac-1112 MIC: 3.77 μg/ml (1.09877 μM)
2 Target: B. subtilis VKM B-501 MIC: 2.06 μg/ml (0.60039 μM)
3 Target: E. coli DH5-alpha MIC: 2.06 μg/ml (0.60039 μM)
4 Target: E. coli MH1 MIC: 2.06 μg/ml (0.60039 μM)
5 Target: P. aeruginosa PAO1 MIC: 61.76 μg/ml (18.0001 μM)
6 Target: P. pastoris GS115 MIC: 126.95 μg/ml (36.9998 μM)
7 Target: S. cerevisiae Y190 MIC: 126.95 μg/ml (36.9998 μM)

Reference
[1] Karpunin D.V.,Surovoy A.Y.,Feofanov A.V.,Vassilevski A.A.,Kozlov S.A.,
Title:Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity.
Journal:J. Biol. Chem., 2006, 281, 20983-20992 [PubMed:16735513]