Record in detail


General Info

  • lamp_id:L01A000081
  • Name:CAP18_RABIT
  • FullName:Antimicrobial protein CAP18
  • Source:Oryctolagus cuniculus
  • Mass:2553.2 Da
  • Sequence Length:20 aa
  • Isoelectric Point:12.55
  • Activity:Antibacterial
  • Sequence
        GLRKRLRKFRNKIKEKLKKI
  • Function:CAP18 binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Has antibiotic activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L11A011801    From 1 To 20 E-value: 0.00009 Score: 37
        GLRKRLRKFRNKIKEKLKKI
  • 2. L11A013097    From 1 To 20 E-value: 0.00009 Score: 37
        GLRKRLRKFRNKIKEKLKKI
  • 3. L11A011802    From 1 To 20 E-value: 0.00009 Score: 37
        GLRKRLRKFRNKIKEKLKKI
  • 4. L11A011798    From 1 To 20 E-value: 0.0001 Score: 37
        GLRKRLRKFRNKIKEKLKKI
  • 5. L11A013096    From 1 To 20 E-value: 0.0001 Score: 37
        GLRKRLRKFRNKIKEKLKKI

Structure

  •   Domains
  •   1  Name:Cathelicidin    Interpro Link:IPR001894
  •   2  Name:Cathelicidin_CS    Interpro Link:IPR018216
  •   3  Name:Cathlecidin_C    Interpro Link:IPR022746
  •   Structures

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Yen M.H.,Hirata M.,Palings I.,Morgan J.G.,Larrick J.W.,
  •   Title:Complementary DNA sequence of rabbit CAP18 -- a unique lipopolysaccharide binding protein.
  •   Journal:Biochem. Biophys. Res. Commun., 1991, 179, 170-175  [MEDLINE:91354246]
  •   [2]  Bolin D.,Zhong J.,Zheng H.,Hirata M.,Larrick J.W.,
  •   Title:A novel granulocyte-derived peptide with lipopolysaccharide-neutralizing activity.
  •   Journal:J. Immunol., 1994, 152, 231-240  [MEDLINE:94075827]
  •   [3]  Palings I.,Morgan J.G.,Yoshida M.,Shimomura Y.,Hirata M.,
  •   Title:Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity.
  •   Journal:Infect. Immun., 1994, 62, 1421-1426  [MEDLINE:94178952]
  •   [4]  Gennaro R.,Skerlavaj B.,Scocchi M.,Tossi A.,
  •   Title:Identification and characterization of a primary antibacterial domain in CAP18, a lipopolysaccharide binding protein from rabbit leukocytes.
  •   Journal:FEBS Lett., 1994, 339, 108-112  [MEDLINE:94148064]
  •   [5]  Larrick J.W.,Chou P.-J.,Luh F.,Brock R.,Chen C.,
  •   Title:The solution structure of the active domain of CAP18 -- a lipopolysaccharide binding protein from rabbit leukocytes.
  •   Journal:FEBS Lett., 1995, 370, 46-52  [MEDLINE:95377455]

Comments

  •   Comments

    •     No comments found on LAMP database



CAPTCHA Image   Reload Image
Enter Code*: