Record in detail


General Info

  • lamp_id:L01A000095
  • Name:H1_ONCMY
  • FullName:Histone H1
  • Source:Oncorhynchus mykiss
  • Mass:7033.7 Da
  • Sequence Length:69 aa
  • Isoelectric Point:12.26
  • Activity:Antibacterial
  • Sequence
        KAVAAKKSPKKAKKPATPKKAAKSPKKVKKPAAAAKKAAKSPKKATKAAKPKAAKPKAAKAKKAAPKKK
  • Function:Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.

Cross-Linking

  •   Cross-linking
  •   1  Database:APD  411
  •   2  Database:CAMP  CAMPSQ85
  •   3  Database:DBAASP  2147
  •   4  Database:dbAMP  dbAMP_04958
  •   5  Database:DRAMP  DRAMP02336
  •   6  Database:Uniprot  P06350

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000095    From 1 To 69 E-value: 2e-20 Score: 89.4
        KAVAAKKSPKKAKKPATPKKAAKSPKKVKKPAAAAKKAAKSPKKATKAAKPKAAKPKAAKAKKAAPKKK

Structure

  •   Domains
  •   1  Name:Histone_H1/H5    Interpro Link:IPR005818
  •   2  Name:Histone_H5    Interpro Link:IPR005819
  •   3  Name:WHTH_trsnscrt_rep_DNA-bd    Interpro Link:IPR011991
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  P. citreus  MIC:  0.2 μg/ml  (0.0284345 μM)  
  •   2  Target:  M.luteus  MIC:  0.2 μg/ml  (0.0284345 μM)  
  •   3  Target:  E. coli  MIC:  0.4 μg/ml  (0.0568691 μM)  
  •   4  Target:  L. anguillarum  MIC:  0.4 μg/ml  (0.0568691 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Dixon G.H.,Winkfein R.J.,Connor W.,Mezquita J.,
  •   Title:An H1 histone gene from rainbow trout (Salmo gairdnerii).
  •   Journal:J. Mol. Evol., 1984, 21, 209-219  [MEDLINE:85264847]
  •   [2]  Smith V.J.,Kemp G.D.,Molle G.,Fernandes J.M.O.,
  •   Title:Isolation and characterisation of oncorhyncin II, a histone H1-derived antimicrobial peptide from skin secretions of rainbow trout, Oncorhynchus mykiss.
  •   Journal:Dev. Comp. Immunol., 2004, 28, 127-138  [PubMed:12969798]

Comments

  •   Comments

    •     No comments found on LAMP database



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