Record in detail


General Info

  • lamp_id:L01A000097
  • Name:H2A_ONCMY
  • FullName:Histone H2A
  • Source:Oncorhynchus mykiss
  • Mass:1202.4 Da
  • Sequence Length:12 aa
  • Isoelectric Point:6.34
  • Activity:Antibacterial, Antifungal
  • Sequence
        AERVGAGAPVYL
  • Function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000097    From 1 To 12 E-value: 0.093 Score: 26.2
        AERVGAGAPVYL
  • 2. L12A11015|    From 40 To 51 E-value: 0.13 Score: 25.8
        AQRVGAGAPVYL
  • 3. L12A09319|    From 41 To 52 E-value: 0.21 Score: 25
        AHRVGAGAPVYL
  • 4. L01A002852    From 40 To 51 E-value: 0.22 Score: 25
        AHRVGAGAPVYL
  • 5. L13A013070    From 1 To 11 E-value: 0.32 Score: 24.6
        AERVGAGAPVY

Structure

  •   Domains
  •   1  Name:Histone-fold    Interpro Link:IPR009072
  •   2  Name:Histone_core_D    Interpro Link:IPR007125
  •   3  Name:Histone_H2A    Interpro Link:IPR002119
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  A. viridans  MIC:  0.06 μg/ml  (0.0499002 μM)  
  •   2  Target:  B. subtilis  MIC:  0.25 μg/ml  (0.207917 μM)  
  •   3  Target:  M. luteus  MIC:  0.12 μg/ml  (0.0998004 μM)  
  •   4  Target:  P. citreus  MIC:  0.06 μg/ml  (0.0499002 μM)  
  •   5  Target:  R. salmoninarum S. aureus A. hydrophila  MIC:  0.6 μg/ml  (0.499002 μM)  
  •   6  Target:  A. salmonicida 004  MIC:  0.6 μg/ml  (0.499002 μM)  
  •   7  Target:  A. salmonicida 849 E. coli  MIC:  0.25 μg/ml  (0.207917 μM)  
  •   8  Target:  L. anguillarum  MIC:  0.25 μg/ml  (0.207917 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Dixon G.H.,Candido E.P.M.,
  •   Title:Acetylation of trout testis histones in vivo. Site of the modification in histone IIb 1.
  •   Journal:J. Biol. Chem., 1972, 247, 3868-3873  [MEDLINE:72206029]
  •   [2]  Dixon G.H.,Bailey G.S.,
  •   Title:Histone IIb1 from rainbow trout. Comparison in amino acid sequence with calf thymus IIB1.
  •   Journal:J. Biol. Chem., 1973, 248, 5463-5472  [MEDLINE:74071618]
  •   [3]  Dixon G.H.,Mezquita J.,States J.C.,Connor W.,
  •   Title:Organization and nucleotide sequence of rainbow trout histone H2A and H3 genes.
  •   Journal:J. Mol. Evol., 1984, 20, 236-250  [MEDLINE:85083109]
  •   [4]  Davie J.R.,Nickel B.E.,
  •   Title:Structure of polyubiquitinated histone H2A.
  •   Journal:Biochemistry, 1989, 28, 964-968  [PubMed:2540826]
  •   [5]  Smith V.J.,Molle M.G.,Kemp G.D.,Fernandes J.M.O.,
  •   Title:Anti-microbial properties of histone H2A from skin secretions of rainbow trout, Oncorhynchus mykiss.
  •   Journal:Biochem. J., 2002, 368, 611-620  [MEDLINE:22328644]

Comments

  •   Comments

    •     No comments found on LAMP database



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