Record in detail
General Info
- lamp_id:L01A000117
- Name:LANN_LACLL
- FullName:Lantibiotic nisin-A
- Source:Lactococcus lactis subsp. lactis
- Mass:3498.2 Da
- Sequence Length:34 aa
- Isoelectric Point:8.52
- Activity:Antibacterial
- Sequence
ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK - Function:Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
Cross-Linking
- Cross-linking
- 1 Database:APD 205
- 2 Database:CAMP CAMPSQ107
- 3 Database:dbAMP dbAMP_04906
- 4 Database:DRAMP DRAMP00036
- 5 Database:SATPdb satpdb18469
- 6 Database:Uniprot P13068
- 7 Database:BAC BAC047
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L12A09408| From 24 To 57 E-value: 0.00000000000001 Score: 70.1
ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK - 2. L12A01034| From 20 To 53 E-value: 0.00000000000001 Score: 70.1
ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK - 3. L01A000117 From 1 To 34 E-value: 0.00000000000004 Score: 68.6
ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK - 4. L12A09409| From 24 To 57 E-value: 0.00000000000005 Score: 68.2
ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK - 5. L12A01035| From 20 To 53 E-value: 0.00000000000006 Score: 68.2
ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Morell J.L.,Gross E.,
- Title:The structure of nisin.
- Journal:J. Am. Chem. Soc., 1971, 93, 4634-4635 [MEDLINE:72072901]
- [2] Hansen J.N.,Banerjee S.,Buchman G.W.,
- Title:Structure, expression, and evolution of a gene encoding the precursor of nisin, a small protein antibiotic.
- Journal:J. Biol. Chem., 1988, 263, 16260-16266 [MEDLINE:89034093]
- [3] Entian K.-D.,Kaletta C.,
- Title:Nisin, a peptide antibiotic: cloning and sequencing of the nisA gene and posttranslational processing of its peptide product.
- Journal:J. Bacteriol., 1989, 171, 1597-1601 [MEDLINE:89155467]
- [4] Hansen J.N.,Chung Y.J.,Steen M.T.,
- Title:Characterization of the nisin gene as part of a polycistronic operon in the chromosome of Lactococcus lactis ATCC 11454.
- Journal:Appl. Environ. Microbiol., 1991, 57, 1181-1188 [MEDLINE:91282469]
- [5] Hilbers C.W.,Konings R.N.H.,van den Hooven H.W.,van de Ven F.J.,
- Title:NMR studies of lantibiotics. The structure of nisin in aqueous solution.
- Journal:Eur. J. Biochem., 1991, 202, 1181-1188 [MEDLINE:92111494]
- [6] Entian K.-D.,Hammelmann M.,Gutowski-Eckel Z.,Engelke G.,
- Title:Biosynthesis of the lantibiotic nisin: genomic organization and membrane localization of the NisB protein.
- Journal:Appl. Environ. Microbiol., 1992, 58, 3730-3743 [MEDLINE:93128945]
- [7] Bycroft B.W.,Roberts G.C.K.,Morley S.D.,Chan W.C.,Lian L.-Y.,
- Title:Solution structures of nisin A and its two major degradation products determined by NMR.
- Journal:Biochem. J., 1992, 283, 413-420 [MEDLINE:92246867]
- [8] Stiles M.E.,Niemczura W.P.,Henkel T.,Helms G.L.,Sailer M.,
- Title:15N- and 13C-labeled media from Anabaena sp. for universal isotopic labeling of bacteriocins: NMR resonance assignments of leucocin A from Leuconostoc gelidum and nisin A from Lactococcus lactis.
- Journal:Biochemistry, 1993, 32, 310-318 [MEDLINE:93120109]
- [9] de Vos W.M.,Siezen R.J.,Beerthuyzen M.M.,Kuipers O.P.,
- Title:Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity.
- Journal:Eur. J. Biochem., 1993, 216, 281-291 [MEDLINE:93373937]
- [10] Hilbers C.W.,Konings R.N.H.,Rollema H.S.,Fogolari F.,van den Hooven H.W.,
- Title:NMR and circular dichroism studies of the lantibiotic nisin in non-aqueous environments.
- Journal:FEBS Lett., 1993, 319, 189-194 [MEDLINE:93202265]
Comments
- Comments
No comments found on LAMP database