Record in detail

lamp_id:L01A000118
Name:LANP_STAEP
FullName:Lantibiotic Pep5
Source:Staphylococcus epidermidis
Mass:3595.3 Da
Sequence Length:34 aa
Isoelectric Point:11.08
Activity:Antibacterial
Sequence
TAGPAIRASVKQCQKTLKATRLFTVSCKGKNGCK
Function:Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

Top similar AMPs on LAMP
1. L12A08159| From 27 To 60 E-value: 0.000000000000009 Score: 70.5
TAGPAIRASVKQCQKTLKATRLFTVSCKGKNGCK
2. L01A000118 From 1 To 34 E-value: 0.00000000000003 Score: 68.9
TAGPAIRASVKQCQKTLKATRLFTVSCKGKNGCK
3. L12A06768| From 27 To 56 E-value: 0.069 Score: 27.7
SLGPAIKATRQVCPK---ATRFVTVSCK-KSDCQ
4. L01A000332 From 3 To 30 E-value: 0.11 Score: 26.9
GPAIKATRQVCPK---ATRFVTVSCK-KSDCQ

Reference
[1] Reis M.,Jung G.,Kellner R.,Entian K.-D.,Kaletta C.,
Title:Pep5, a new lantibiotic: structural gene isolation and prepeptide sequence.
Journal:Arch. Microbiol., 1989, 152, 16-19 [MEDLINE:89350399]
[2] Jung G.,Stevanovic S.,Metzger J.,Beck-Sickinger A.G.,Weil H.-P.,
Title:Biosynthesis of the lantibiotic Pep5. Isolation and characterization of a prepeptide containing dehydroamino acids.
Journal:Eur. J. Biochem., 1990, 194, 217-223 [MEDLINE:91071193]
[3] Suling J.,Reis M.,Heidrich C.,Bierbaum G.,Meyer C.,
Title:Nucleotide sequence of the lantibiotic Pep5 biosynthetic gene cluster and functional analysis of PepP and PepC. Evidence for a role of PepC in thioether formation.
Journal:Eur. J. Biochem., 1995, 232, 478-489 [MEDLINE:96035882]