Record in detail

lamp_id:L01A000122
Name:MAGA_XENLA
FullName:Magainins
Source:Xenopus laevis
Mass:2466.9 Da
Sequence Length:23 aa
Isoelectric Point:10.8
Activity:Antibacterial, Antifungal, Antiparasitic,Anticancer
Sequence
GIGKFLHSAKKFGKAFVGEIMNS
Function:Antimicrobial peptides that inhibit the growth of numerous species of bacteria and fungi and induce osmotic lysis of protozoa. Magainins are membrane lytic agents.

Top similar AMPs on LAMP
1. L13A021655 From 21 To 43 E-value: 0.00000003 Score: 48.9
GIGKFLHSAKKFGKAFVGEIMNS
2. L13A021739 From 11 To 33 E-value: 0.00000003 Score: 48.5
GIGKFLHSAKKFGKAFVGEIMNS
3. L13A027268 From 11 To 33 E-value: 0.00000004 Score: 48.5
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4. L13A013667 From 11 To 33 E-value: 0.00000007 Score: 47.4
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5. L13A013107 From 1 To 23 E-value: 0.00000007 Score: 47.4
GIGKFLHSAKKFGKAFVGEIMNS

Antibacterial Activities
1 Target: [ Refer PubMed : 3299384 :- Escherichia coli D31 MIC: 5 μg/ml (2.02684 μM)
2 Target: Klebsiella pneumoniae MIC: 10 μg/ml (4.05367 μM)
3 Target: Pseudomonas putida MIC: 10 μg/ml (4.05367 μM)
4 Target: Staphylococcus epidermidis MIC: 10 μg/ml (4.05367 μM)
5 Target: Citrobacter freundii MIC: 30 μg/ml (12.161 μM)
6 Target: Enterobacter cloacae MIC: 50 μg/ml (20.2684 μM)
7 Target: Escherichia coli MIC: 50 μg/ml (20.2684 μM)
8 Target: Staphylococcus aureus MIC: 50 μg/ml (20.2684 μM)
9 Target: Candida albicans MIC: 80 μg/ml (32.4294 μM)
10 Target: Pseudomonas aeruginosa MIC: 100 μg/ml (40.5367 μM)
11 Target: Serratia marcescens MIC: 100 μg/ml (40.5367 μM)
12 Target: Proteus mirabilis MIC: 100 μg/ml (40.5367 μM)
13 Target: Streptococcus fecalis MIC: 100 μg/ml (40.5367 μM)
14 Target: Paramecium caudatum MIC: 10 μg/ml (4.05367 μM)
15 Target: Amoeba proteus Euglena gracilis ] [ Refer PubMed MIC: 62 μg/ml (25.1328 μM)
16 Target: Klebsiella Pneumonae ATCC 13883 MIC: 125 μg/ml (50.6709 μM)
17 Target: Pseudomonas aeruginosa ATCC 27853 MIC: 125 μg/ml (50.6709 μM)
18 Target: Staphylococcus aureus ATCC 29213 MIC: 500 μg/ml (202.684 μM)
19 Target: Streptococcus faecalis ATCC 29212 MIC: 500 μg/ml (202.684 μM)
20 Target: Candida ablicans ATCC 14053 MIC: 250 μg/ml (101.342 μM)

Reference
[1] Zasloff M.
Title:Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.
Journal:Proc. Natl. Acad. Sci. U.S.A., 1987, 84, 5449-5453 [MEDLINE:87261003]
[2] Giovannini M.G.,Nutkins J.C.,Williams D.H.,Poulter L.,Terry A.S.,
Title:The cDNA sequence coding for prepro-PGS (prepro-magainins) and aspects of the processing of this prepro-polypeptide.
Journal:J. Biol. Chem., 1988, 263, 5745-5751 [MEDLINE:88186892]
[3] Turner K.,Tomassini N.,Brasseur M.M.,Bevins C.L.,Moore K.S.,
Title:Antimicrobial peptides in the stomach of Xenopus laevis.
Journal:J. Biol. Chem., 1991, 266, 19851-19857 [MEDLINE:92011794]
[4] Opella S.J.,Zasloff M.,Bechinger B.,
Title:Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy.
Journal:Protein Sci., 1993, 2, 2077-2084 [MEDLINE:94129391]