Record in detail
General Info
- lamp_id:L01A000128
- Name:PENK_BOVIN
- FullName:Proenkephalin-A
- Source:Bos taurus
- Mass:3358.6 Da
- Sequence Length:29 aa
- Isoelectric Point:3.95
- Activity:Antibacterial
- Sequence
FAEPTBSEEEGESYSKEVPEMEKRYGGFM - Function:Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(111-130) and PENK(233-254) increase glutamate release in the striatum. PENK(111-130) decreases GABA concentration in the striatum.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ116
- 2 Database:dbAMP dbAMP_01586
- 3 Database:Uniprot P01211
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A000128 From 1 To 29 E-value: 0.00000000005 Score: 58.2
FAEPTBSEEEGESYSKEVPEMEKRYGGFM - 2. L03A000063 From 3 To 31 E-value: 0.000000001 Score: 53.5
FAEPLPSEEEGESYSKEVPEMEKRYGGFM - 3. L01A002850 From 1 To 29 E-value: 0.000000001 Score: 53.5
FAEPLPSEEEGESYSKEVPEMEKRYGGFM - 4. L02A000812 From 1 To 29 E-value: 0.000000008 Score: 50.8
FAEPLPSEEEGESYSKEPPEMEKRYGGFM - 5. L11A000647 From 1 To 29 E-value: 0.0006 Score: 34.7
FAEPLPSEEEGEXYXKEVPEMEKRYGGFM
Activity
- Antibacterial Activities
- 1 Target: M.luteus MIC: 0.67 μg/ml (0.199488 μM)
- 2 Target: B.megaterium MIC: 0.67 μg/ml (0.199488 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Hirose T.,Toyosato M.,Takahashi H.,Furutani Y.,Noda M.,
- Title:Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin.
- Journal:Nature, 1982, 295, 202-206 [MEDLINE:82125409]
- [2] Udenfriend S.,Gage L.P.,Hoffman B.J.,Seeburg P.,Gubler U.,
- Title:Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides.
- Journal:Nature, 1982, 295, 206-208 [MEDLINE:82125410]
- [3] Crea R.,Herbert E.,Comb M.,
- Title:Partial characterization of the mRNA that codes for enkephalins in bovine adrenal medulla and human pheochromocytoma.
- Journal:Proc. Natl. Acad. Sci. U.S.A., 1982, 79, 360-364 [MEDLINE:82197495]
- [4] Poteur L.,Nulans G.,Moniatte M.,Strub J.-M.,Goumon Y.,
- Title:The C-terminal bisphosphorylated proenkephalin-A-(209-237)-peptide from adrenal medullary chromaffin granules possesses antibacterial activity.
- Journal:Eur. J. Biochem., 1996, 235, 516-525 [MEDLINE:96184524]
Comments
- Comments
No comments found on LAMP database