Record in detail

lamp_id:L01A000178
Name:LEB1_GALME
FullName:Lebocin-like anionic peptide 1
Source:Galleria mellonella
Mass:4819.3 Da
Sequence Length:42 aa
Isoelectric Point:4.3
Activity:Antibacterial, Antifungal
Sequence
EADEPLWLYKGDNIERAPTTADHPILPSIIDDVKLDPNRRYA
Function:Antimicrobial protein. Has antibacterial activity against the Gram-positive bacteria M.luteus (MIC=22.7 uM) and L.monocytogenes (MIC=90.9 uM). Lacks antibacterial activity against the Gram-positive bacteria B.circulans, S.aureus, and S.lutea, and the Gram-negative bacteria E.coli D31, E.coli ATCC 25922, and S.typhimurium. Has antifungal activity against A.niger (MIC=90.9 uM) and T.harzianum (MIC=90.9 uM), but lacks antifungal activity against S.cerevisiae, P.pastoris, Z.marxianus, C.albicans, C.fructus, and F.oxysporum.

Top similar AMPs on LAMP
1. L01A000178 From 1 To 42 E-value: 1e-19 Score: 87
EADEPLWLYKGDNIERAPTTADHPILPSIIDDVKLDPNRRYA
2. L11A004128 From 3 To 43 E-value: 0.00000000000001 Score: 70.5
GNEPLWLYQGDNIPKAPSTAEHPFLPSIIDDVKFNPDRRYA
3. L11A004127 From 3 To 43 E-value: 0.00000000000001 Score: 70.1
GNEPLWLYQGDNIPKAPSTAEHPFLPSIIDDVKFNPDRRYA

Antibacterial Activities
1 Target: M. luteus MIC: 109.4 μg/ml (22.7004 μM)
2 Target: L.monocytogenes MIC: 438.07 μg/ml (90.8991 μM)
3 Target: A.niger MIC: 438.07 μg/ml (90.8991 μM)
4 Target: T.harzianum MIC: 438.07 μg/ml (90.8991 μM)

Reference
[1] Jakubowicz T.,Suder P.,Zdybicka-Barabas A.,Mak P.,Cytrynska M.,
Title:Purification and characterization of eight peptides from Galleria mellonella immune hemolymph.
Journal:Peptides, 2007, 28, 533-546 [PubMed:17194500]