Record in detail

lamp_id:L01A000182
Name:PLEA2_RANAP
FullName:Pleurain-A2
Source:Rana pleuraden
Mass:3027.6 Da
Sequence Length:26 aa
Isoelectric Point:9.46
Activity:Antibacterial, Antifungal
Sequence
SIITMTKEAKLPQSWKQIACRLYNTC
Function:Antimicrobial peptide. Has activity against the Gram-positive bacterium S.aureus ATCC2592 (MIC=15 ug/ml), the Gram-negative bacteria E.coli ATCC25922 (MIC=60 ug/ml), B.dysenteriae (MIC=60 ug/ml), H.pylori NTCT11637 (MIC=30 ug/ml), and the fungus C.albicans ATCC2002 (MIC=30 ug/ml). Has little hemolytic activity on rabbit red blood cells.

Top similar AMPs on LAMP
1. L12A07199| From 44 To 69 E-value: 0.00000000006 Score: 58.2
SIITMTKEAKLPQSWKQIACRLYNTC
2. L01A000182 From 1 To 26 E-value: 0.0000000002 Score: 56.2
SIITMTKEAKLPQSWKQIACRLYNTC
3. L12A07191| From 44 To 69 E-value: 0.0000000004 Score: 55.1
SIITMTKEAKLPQLWKQIACRLYNTC
4. L01A000173 From 1 To 26 E-value: 0.000000001 Score: 53.9
SIITMTKEAKLPQLWKQIACRLYNTC
5. L01A003325 From 1 To 26 E-value: 0.000000002 Score: 53.1
SIITMTREAKLPQLWKQIACRLYNTC

Antibacterial Activities
1 Target: Escherichia coli ATCC 25922 MIC: 60 μg/ml (19.8177 μM)
2 Target: Bacillus dysenteriae MIC: 60 μg/ml (19.8177 μM)
3 Target: Helicobacter pylori NCTC 11637 MIC: 30 μg/ml (9.90884 μM)
4 Target: Staphylococcus aureus ATCC 2592 MIC: 15 μg/ml (4.95442 μM)
5 Target: Candida albicans ATCC 2002 MIC: 30 μg/ml (9.90884 μM)
6 Target: E. coli MIC: 60.0676 μg/ml (19.84 μM)
7 Target: S. aureus MIC: 15.0169 μg/ml (4.96 μM)

Reference
[1] Xu X.,Liu H.,Li J.,Song Y.,Wang X.,
Title:A new family of antimicrobial peptides from skin secretions of Rana pleuraden.
Journal:Peptides, 2007, 28, 2069-2074 [PubMed:17764786]