Record in detail


General Info

  • lamp_id:L01A000202
  • Name:B1DYB_RANDY
  • FullName:Brevinin-1DYb
  • Source:Rana dybowskii
  • Mass:2239.8 Da
  • Sequence Length:20 aa
  • Isoelectric Point:9.67
  • Activity:Antibacterial
  • Sequence
        FLSLALAALPKLFCLIFKKC
  • Function:Antimicrobial peptide. Has low activity against the Gram-positive bacterium S.aureus and the Gram-negative bacterium E.coli (MIC<15 uM). Has a strong hemolytic activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A07052|    From 48 To 67 E-value: 0.000008 Score: 40.4
        FLSLALAALPKLFCLIFKKC
  • 2. L12A07104|    From 47 To 66 E-value: 0.000009 Score: 40.4
        FLSLALAALPKLFCLIFKKC
  • 3. L12A07017|    From 49 To 67 E-value: 0.00003 Score: 38.5
        LSLALAALPKLFCLIFKKC
  • 4. L01A000202    From 1 To 20 E-value: 0.00003 Score: 38.5
        FLSLALAALPKLFCLIFKKC
  • 5. L13A028928    From 1 To 19 E-value: 0.0001 Score: 36.6
        LSLALAALPKLFCLIFKKC

Structure

  •   Domains
  •   1  Name:Antimicrobial_frog_1    Interpro Link:IPR012520
  •   2  Name:Brevinin    Interpro Link:IPR004275
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  223.98 μg/ml  (100 μM)  
  •   2  Target:  S. aureus  MIC:  29.1174 μg/ml  (13 μM)  

Toxicity

  •   Toxicity

Reference

  •   Reference
  •   [1]  Vaudry H.,Leprince J.,Nowotny N.,Kolodziejek J.,Conlon J.M.,
  •   Title:Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii.
  •   Journal:Toxicon, 2007, 50, 746-756  [PubMed:17688900]
  •   [2]  Zhang D.-B.,Feng K.,Song S.-S.,Li Q.,Jin L.-L.,
  •   Title:Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii.
  •   Journal:Comp. Biochem. Physiol., 2009, 154, 174-178  [PubMed:19539775]

Comments

  •   Comments

    •     No comments found on LAMP database



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