Record in detail
General Info
- lamp_id:L01A000212
- Name:DEFA2_MOUSE
- FullName:Alpha-defensin 2
- Source:Mus musculus
- Mass:4253.1 Da
- Sequence Length:35 aa
- Isoelectric Point:10.02
- Activity:Antibacterial
- Sequence
LRDLVCYCRTRGCKRRERMNGTCRKGHLMYTLCCR - Function:Has broad-spectrum antimicrobial properties. Has antibacterial activity against the Gram-positive bacterium L.monocytogenes EGD and the Gram-negative bacteria E.coli ML-35p and avirulent S.typhimurium 7953, but not against the mouse-virulent S.typhimurium 14028S. Probably contributes to the antimicrobial barrier function of the small bowel mucosa.
Cross-Linking
- Cross-linking
- 1 Database:APD 137
- 2 Database:CAMP CAMPSQ191
- 3 Database:DBAASP 7701
- 4 Database:dbAMP dbAMP_05994
- 5 Database:DRAMP DRAMP03330
- 6 Database:SATPdb satpdb12305
- 7 Database:Uniprot P28309
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000165 From 59 To 93 E-value: 3e-16 Score: 75.9
LRDLVCYCRTRGCKRRERMNGTCRKGHLMYTLCCR - 2. L12A08327| From 59 To 93 E-value: 8e-16 Score: 73.9
LRDLVCYCRTRGCKRRERMNGTCRKGHLIYTLCCR - 3. L03A000003 From 51 To 85 E-value: 0.000000000000001 Score: 73.6
LRDLVCYCRTRGCKRRERMNGTCRKGHLMHTLCCR - 4. L03A000176 From 59 To 93 E-value: 0.000000000000001 Score: 73.6
LRDLVCYCRTRGCKRREHMNGTCRKGHLMYTLCCR - 5. L03A000182 From 59 To 93 E-value: 0.000000000000002 Score: 73.2
LRDLVCYCRKRGCKRRERMNGTCRKGHLMYTLCCR
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Lehrer R.I.,Harwig S.S.S.L.,Eisenhauer P.B.,
- Title:Cryptdins: antimicrobial defensins of the murine small intestine.
- Journal:Infect. Immun., 1992, 60, 3556-3565 [PubMed:1500163]
- [2] Ouellette A.J.,Henschen A.H.,Miller S.I.,Selsted M.E.,
- Title:Enteric defensins: antibiotic peptide components of intestinal host defense.
- Journal:J. Cell Biol., 1992, 118, 929-936 [MEDLINE:92363933]
- [3] Takahashi N.,Hagen M.D.,Horton J.H.,Wang X.,Ko M.S.,
- Title:Genetic mapping of 40 cDNA clones on the mouse genome by PCR.
- Journal:Mamm. Genome, 1994, 5, 349-355 [MEDLINE:94319082]
- [4] Ouellette A.J.,Selsted M.E.,Huttner K.M.,
- Title:Structure and diversity of the murine cryptdin gene family.
- Journal:Genomics, 1994, 19, 448-453 [MEDLINE:94245232]
Comments
- Comments
No comments found on LAMP database