Record in detail


General Info

  • lamp_id:L01A000217
  • Name:CTHL6_BOVIN
  • FullName:Cathelicidin-6
  • Source:Bos taurus
  • Mass:3283.1 Da
  • Sequence Length:27 aa
  • Isoelectric Point:12.84
  • Activity:Antibacterial, Antifungal,Anticancer
  • Sequence
        GRFKRFRKKFKKLFKKLSPVIPLLHLG
  • Function:Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L11A012537    From 4 To 30 E-value: 0.000000005 Score: 51.6
        GRFKRFRKKFKKLFKKLSPVIPLLHLG
  • 2. L01A000217    From 1 To 27 E-value: 0.000000005 Score: 51.6
        GRFKRFRKKFKKLFKKLSPVIPLLHLG
  • 3. L13A024579    From 1 To 26 E-value: 0.00000003 Score: 49.3
        GRFKRFRKKFKKLFKKLSPVIPLLHL
  • 4. L13A013682    From 1 To 26 E-value: 0.00000003 Score: 49.3
        GRFKRFRKKFKKLFKKLSPVIPLLHL
  • 5. L12A03978|    From 1 To 26 E-value: 0.00000003 Score: 49.3
        GRFKRFRKKFKKLFKKLSPVIPLLHL

Structure

  •   Domains
  •   1  Name:Cathelicidin    Interpro Link:IPR001894
  •   2  Name:Cathelicidin_CS    Interpro Link:IPR018216
  •   Structures

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli ATCC25922  MIC:  3.28 μg/ml  (0.999056 μM)  
  •   2  Target:  E. coli ML35  MIC:  3.28 μg/ml  (0.999056 μM)  
  •   3  Target:  E.coli D21  MIC:  0.82 μg/ml  (0.249764 μM)  
  •   4  Target:  S. typhimurium ATCC 14028  MIC:  3.28 μg/ml  (0.999056 μM)  
  •   5  Target:  P. aeruginosa ATCC 27853  MIC:  3.28 μg/ml  (0.999056 μM)  
  •   6  Target:  S. marcescens ATCC 8100  MIC:  6.57 μg/ml  (2.00116 μM)  
  •   7  Target:  S. aureus ATCC 25923  MIC:  6.57 μg/ml  (2.00116 μM)  
  •   8  Target:  S. aureus Cowan 1  MIC:  6.57 μg/ml  (2.00116 μM)  
  •   9  Target:  S. aureus MRSA  MIC:  13.13 μg/ml  (3.99927 μM)  
  •   10  Target:  S. epidermidis ATCC 12228  MIC:  3.28 μg/ml  (0.999056 μM)  
  •   11  Target:  B. megaterium Bm11  MIC:  6.57 μg/ml  (2.00116 μM)  
  •   12  Target:  C.albicans  MIC:  26.26 μg/ml  (7.99854 μM)  
  •   13  Target:  C.neoformans  MIC:  13.13 μg/ml  (3.99927 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Risso A.,Merluzzi L.,Bagella L.,Gennaro R.,Skerlavaj B.,
  •   Title:Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.
  •   Journal:J. Biol. Chem., 1996, 271, 28375-28381  [MEDLINE:97067059]
  •   [2]  Womack J.E.,Elliott J.S.,Seabury C.M.,Gillenwaters E.N.,
  •   Title:Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family.
  •   Journal:J. Hered., 2009, 100, 241-245  [PubMed:19136450]

Comments

  •   Comments

    •     No comments found on LAMP database



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