Record in detail


General Info

  • lamp_id:L01A000220
  • Name:PMP37_PIG
  • FullName:Antibacterial peptide PMAP-37
  • Source:Sus scrofa
  • Mass:4365 Da
  • Sequence Length:37 aa
  • Isoelectric Point:10.99
  • Activity:Antibacterial
  • Sequence
        GLLSRLRDFLSDRGRRLGEKIERIGQKIKDLSEFFQS
  • Function:Exerts antimicrobial activity against both Gram-positive and negative bacteria with minimal inhibitory concentrations ranging over 1-4 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000220    From 1 To 37 E-value: 0.000000000000007 Score: 70.9
        GLLSRLRDFLSDRGRRLGEKIERIGQKIKDLSEFFQS
  • 2. L01A002675    From 1 To 33 E-value: 0.001 Score: 33.5
        RLKELITTGGQKIGEKIRRIGQRIKDFFKNLQP
  • 3. L11A002031    From 1 To 31 E-value: 0.003 Score: 32.3
        ISRLAGLLRKGGEKIGEKLKKIGQKIKN---FFQ
  • 4. L01A003119    From 1 To 31 E-value: 0.003 Score: 32.3
        ISRLAGLLRKGGEKIGEKLKKIGQKIKN---FFQ
  • 5. L02A000680    From 1 To 31 E-value: 0.011 Score: 30.4
        GLFGRLRDSLQRGGQKILEKAERIWCKIKDI

Structure

  •   Domains
  •   1  Name:Cathelicidin    Interpro Link:IPR001894
  •   2  Name:Cathelicidin_CS    Interpro Link:IPR018216
  •   3  Name:Cathlecidin_C    Interpro Link:IPR022746
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E.coli ML35  MIC:  8.73 μg/ml  (2 μM)  
  •   2  Target:  E.coli ATCC 25922  MIC:  4.36 μg/ml  (0.998855 μM)  
  •   3  Target:  E.coli D21  MIC:  8.73 μg/ml  (2 μM)  
  •   4  Target:  S.typhimurium ATCC 14028  MIC:  17.46 μg/ml  (4 μM)  
  •   5  Target:  P.aeruginosa ATCC 27853  MIC:  8.73 μg/ml  (2 μM)  
  •   6  Target:  B.megaterium Bm11  MIC:  17.46 μg/ml  (4 μM)  
  •   7  Target:  B.megaterium local isolate  MIC:  17.46 μg/ml  (4 μM)  
  •   8  Target:  S.aureus ATCC 25923  MIC:  139.68 μg/ml  (32 μM)  
  •   9  Target:  S.aureus Cowan 1  MIC:  279.36 μg/ml  (64 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Gennaro R.,Storici P.,Zanetti M.,Scocchi M.,Tossi A.,
  •   Title:PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity.
  •   Journal:Eur. J. Biochem., 1995, 228, 941-946  [MEDLINE:95255306]

Comments

  •   Comments

    •     No comments found on LAMP database



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